3D Models of the Bone Marrow in Health and Disease: Yesterday, Today and Tomorrow

Overview

Journal MRS Commun

Publisher Cambridge University Press

Date 2019 Apr 2

PMID 30931174

Citations 17

Authors

Annamarija Raic

Toufik Naolou

Anna Mohra

Chandralekha Chatterjee

Cornelia Lee-Thedieck

Affiliations

Soon will be listed here.

Abstract

The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyse HSC maintenance and hematopoiesis under steady-state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting) and implementations recapturing bone marrow functions in health and diseases, are presented.

Citing Articles

In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead?.

Mattioda C, Voena C, Ciardelli G, Mattu C Cells. 2025; 14(1.

PMID: 39791739 PMC: 11720277. DOI: 10.3390/cells14010038.

Mesenchymal Stem Cell and Hematopoietic Stem and Progenitor Cell Co-Culture in a Bone-Marrow-on-a-Chip Device toward the Generation and Maintenance of the Hematopoietic Niche.

Kefallinou D, Grigoriou M, Boumpas D, Tserepi A Bioengineering (Basel). 2024; 11(8).

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Generating human bone marrow organoids for disease modeling and drug discovery.

Olijnik A, Rodriguez-Romera A, Wong Z, Shen Y, Reyat J, Jooss N Nat Protoc. 2024; 19(7):2117-2146.

PMID: 38532070 DOI: 10.1038/s41596-024-00971-7.

Emerging Strategies in 3D Culture Models for Hematological Cancers.

Barozzi D, Scielzo C Hemasphere. 2023; 7(8):e932.

PMID: 37520775 PMC: 10378728. DOI: 10.1097/HS9.0000000000000932.

Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesis.

de Janon A, Mantalaris A, Panoskaltsis N J Immunol. 2023; 210(7):895-904.

PMID: 36947817 PMC: 7614371. DOI: 10.4049/jimmunol.2200836.

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