Amorphous Silicon Dioxide Nanoparticles Modulate Immune Responses in a Model of Allergic Contact Dermatitis

Overview

Journal Sci Rep

Specialty Science

Date 2019 Mar 27

PMID 30911099

Citations 12

Authors

Brian C Palmer

Samreen Jatana

Sarah J Phelan-Dickinson

Lisa A DeLouise

Affiliations

Soon will be listed here.

Abstract

Amorphous silicon dioxide nanoparticles (SiNPs) are ubiquitous, and they are currently found in cosmetics, drugs, and foods. Biomedical research is also focused on using these nanoparticles as drug delivery and bio-sensing platforms. Due to the high potential for skin exposure to SiNPs, research into the effect of topical exposure on both healthy and inflammatory skin models is warranted. While we observe only minimal effects of SiNPs on healthy mouse skin, there is an immunomodulatory effect of these NPs in a model of allergic contact dermatitis. The effect appears to be mediated partly by keratinocytes and results in decreases in epidermal hyperplasia, inflammatory cytokine release, immune cell infiltration, and a subsequent reduction in skin swelling. Additional research is required to further our mechanistic understanding and to validate the extent of this immunomodulatory effect in human subjects in order to assess the potential prophylactic use of SiNPs for treating allergic skin conditions.

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