Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery

Overview

Journal AAPS PharmSciTech

Publisher Springer

Date 2025 Jan 13

PMID 39806209

Authors

T Naga Aparna

Rohit Kumar

Shah Raj Ali

Dhaval J Patel

Kazi Julekha

Touseef Begum

Jyoti Bala

Pawan Kumar

Affiliations

Soon will be listed here.

Abstract

The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges. Using SiNPs as vehicles for anti-cancer drug delivery has emerged as a promising strategy due to their unique structural properties, biocompatibility, and versatility. This review explores the various aspects of SiNPs in cancer therapy, highlighting their synthesis, functionalization, and application in delivering chemotherapeutic agents, photosensitizers, and nucleic acids. SiNPs offer advantages such as high drug loading capacity, controlled release, and targeted delivery, enhancing therapeutic efficacy and reducing systemic toxicity. Moreover, this review aims to provide an in-depth understanding of the current state and prospects of SiNPs in revolutionizing cancer treatment and improving patient outcomes.

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