Pathophysiology and Treatment of Obesity-related Hypertension

Overview

Journal J Clin Hypertens (Greenwich)

Specialty Cardiology & Vascular Diseases

Date 2019 Mar 26

PMID 30907058

Citations 24

Authors

Steven G Chrysant

Affiliations

Soon will be listed here.

Abstract

The prevalence of overweight and obesity has increased significantly in the United States and worldwide. Among the many complications of obesity, hypertension is the most common and major one accounting for about 70% in the obese subjects. However, the pathophysiologic factors of obesity-related hypertension and its therapeutic options are not well understood at present. To better understand the pathophysiology of obesity-related hypertension and its treatment options, a Medline search of the English language literature was contacted between 2010 and 2018 and 22 pertinent papers were selected. The information from these papers together with collateral literature will be discussed in this review.

Citing Articles

General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants.

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Analysis of the Energy Expenditure of Sports School Activities in Children.

Gonzalez-Devesa D, Sanchez-Lastra M, Ayan-Perez C, Blanco-Martinez N, Soutullo Rivas M, Vidal-Marino M Children (Basel). 2024; 11(8).

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Weight Misperception is Prevalent Among Turkish Adults and Associated with Higher Age, Body Mass Index and Lower Education Status.

Guven A, Ozdede M, Eroglu B Diabetes Metab Syndr Obes. 2024; 17:2831-2843.

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Association of visceral adiposity index with hypertension (NHANES 2003-2018).

Zhou H, Li T, Li J, Zheng D, Yang J, Zhuang X Front Cardiovasc Med. 2024; 11:1341229.

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Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension.

Liu S, Wang Q, Zhou H, Tong N, Chang R, Wang F Hypertens Res. 2024; 47(8):2157-2171.

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References

Suga S, Itoh H, Komatsu Y, Ishida H, Igaki T, Yamashita J . Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages. Endocrinology. 1998; 139(4):1920-6. DOI: 10.1210/endo.139.4.5918. View

Chughtai H, Morgan T, Rocco M, Stacey B, Brinkley T, Ding J . Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events. Hypertension. 2010; 56(5):901-6. PMC: 3634339. DOI: 10.1161/HYPERTENSIONAHA.110.157370. View

Qasim A, Turcotte M, de Souza R, Samaan M, Champredon D, Dushoff J . On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations. Obes Rev. 2017; 19(2):121-149. DOI: 10.1111/obr.12625. View

Chrysant S . Pathophysiology and treatment of obesity-related hypertension. J Clin Hypertens (Greenwich). 2019; 21(5):555-559. PMC: 8030569. DOI: 10.1111/jch.13518. View

Faulkner J, Belin de Chantemele E . Sex Differences in Mechanisms of Hypertension Associated With Obesity. Hypertension. 2017; 71(1):15-21. PMC: 5730468. DOI: 10.1161/HYPERTENSIONAHA.117.09980. View

Hall J, Crook E, Jones D, Wofford M, Dubbert P . Mechanisms of obesity-associated cardiovascular and renal disease. Am J Med Sci. 2002; 324(3):127-37. DOI: 10.1097/00000441-200209000-00003. View

Achari A, Jain S . Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017; 18(6). PMC: 5486142. DOI: 10.3390/ijms18061321. View

Chrysant S . Pharmacokinetic, pharmacodynamic, and antihypertensive effects of the neprilysin inhibitor LCZ-696: sacubitril/valsartan. J Am Soc Hypertens. 2017; 11(7):461-468. DOI: 10.1016/j.jash.2017.04.012. View

Belin de Chantemele E, Mintz J, Rainey W, Stepp D . Impact of leptin-mediated sympatho-activation on cardiovascular function in obese mice. Hypertension. 2011; 58(2):271-9. PMC: 3141100. DOI: 10.1161/HYPERTENSIONAHA.110.168427. View

10.

Brooks V, Shi Z, Holwerda S, Fadel P . Obesity-induced increases in sympathetic nerve activity: sex matters. Auton Neurosci. 2014; 187:18-26. PMC: 4786002. DOI: 10.1016/j.autneu.2014.11.006. View

11.

Asferg C, Mogelvang R, Flyvbjerg A, Frystyk J, Jensen J, Marott J . Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. Am J Hypertens. 2009; 23(3):327-33. DOI: 10.1038/ajh.2009.244. View

12.

Hall J, Granger J, do Carmo J, da Silva A, Dubinion J, George E . Hypertension: physiology and pathophysiology. Compr Physiol. 2013; 2(4):2393-442. DOI: 10.1002/cphy.c110058. View

13.

Sugerman H, Windsor A, Bessos M, Wolfe L . Intra-abdominal pressure, sagittal abdominal diameter and obesity comorbidity. J Intern Med. 1997; 241(1):71-9. DOI: 10.1046/j.1365-2796.1997.89104000.x. View

14.

Santhekadur P, Kumar D, Seneshaw M, Mirshahi F, Sanyal A . The multifaceted role of natriuretic peptides in metabolic syndrome. Biomed Pharmacother. 2017; 92:826-835. PMC: 5737745. DOI: 10.1016/j.biopha.2017.05.136. View

15.

Engeli S, Sharma A . The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension. J Mol Med (Berl). 2001; 79(1):21-9. DOI: 10.1007/s001090000144. View

16.

Lambert E, Straznicky N, Dixon J, Lambert G . Should the sympathetic nervous system be a target to improve cardiometabolic risk in obesity?. Am J Physiol Heart Circ Physiol. 2015; 309(2):H244-58. DOI: 10.1152/ajpheart.00096.2015. View

17.

Montague C, Prins J, Sanders L, Digby J, ORahilly S . Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes. 1997; 46(3):342-7. DOI: 10.2337/diab.46.3.342. View

18.

Marcus Y, Shefer G, Stern N . Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance. Mol Cell Endocrinol. 2012; 378(1-2):1-14. DOI: 10.1016/j.mce.2012.06.021. View

19.

Cardillo C, Campia U, Iantorno M, Panza J . Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension. 2003; 43(1):36-40. DOI: 10.1161/01.HYP.0000103868.45064.81. View

20.

Shankar A, Xiao J . Positive relationship between plasma leptin level and hypertension. Hypertension. 2010; 56(4):623-8. DOI: 10.1161/HYPERTENSIONAHA.109.148213. View