Environmental Enrichment and Mouse Models: Current Perspectives

Overview

Journal Animal Model Exp Med

Date 2019 Mar 21

PMID 30891552

Citations 35

Authors

Kathryn Bayne

Affiliations

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Abstract

The provision of environmental enrichment to numerous species of laboratory animals is generally considered routine husbandry. However, mouse enrichment has proven to be very complex due to the often contradictory outcomes (animal health and welfare, variability in scientific data, etc.) associated with strain, age of the animal when enrichment is provided, gender of the animal, scientific use of the animal, and other housing attributes. While this has led to some suggesting that mice should not be provided enrichment, more recently opinion is trending toward acknowledging that enrichment actually normalizes the animal and data obtained from a mouse living in a barren environment are likely not to be representative or even reliable. This article offers an overview of the types of impact enrichment can have on various strains of mice and demonstrates that enrichment not only has a role in mouse husbandry, but also can lead to new areas of scientific enquiry in a number of different fields.

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References

van de Weerd H, Van Loo P, van Zutphen L, Koolhaas J, Baumans V . Preferences for nesting material as environmental enrichment for laboratory mice. Lab Anim. 1997; 31(2):133-43. DOI: 10.1258/002367797780600152. View

Pasalic I, Bosnjak B, Tkalcevic V, Jaran D, Javorscak Z, Markovic D . Cage enrichment with paper tissue, but not plastic tunnels, increases variability in mouse model of asthma. Lab Anim. 2010; 45(2):121-3. DOI: 10.1258/la.2010.010109. View

RENNER M, ROSENZWEIG M . Social interactions among rats housed in grouped and enriched conditions. Dev Psychobiol. 1986; 19(4):303-13. DOI: 10.1002/dev.420190403. View

Van Loo P, van der Meer E, Kruitwagen C, Koolhaas J, Van Zutphen L, Baumans V . Long-term effects of husbandry procedures on stress-related parameters in male mice of two strains. Lab Anim. 2004; 38(2):169-77. DOI: 10.1258/002367704322968858. View

Rampon C, Jiang C, Dong H, Tang Y, Lockhart D, Schultz P . Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000; 97(23):12880-4. PMC: 18858. DOI: 10.1073/pnas.97.23.12880. View

Haemisch A, Voss T, Gartner K . Effects of environmental enrichment on aggressive behavior, dominance hierarchies, and endocrine states in male DBA/2J mice. Physiol Behav. 1994; 56(5):1041-8. DOI: 10.1016/0031-9384(94)90341-7. View

Kondo M, Gray L, Pelka G, Christodoulou J, Tam P, Hannan A . Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expression. Eur J Neurosci. 2008; 27(12):3342-50. DOI: 10.1111/j.1460-9568.2008.06305.x. View

Diamond M, Johnson R, Protti A, Ott C, Kajisa L . Plasticity in the 904-day-old male rat cerebral cortex. Exp Neurol. 1985; 87(2):309-17. DOI: 10.1016/0014-4886(85)90221-3. View

Toth L, Kregel K, Leon L, Musch T . Environmental enrichment of laboratory rodents: the answer depends on the question. Comp Med. 2012; 61(4):314-21. PMC: 3155397. View

10.

Marques J, Olsson I . The effect of preweaning and postweaning housing on the behaviour of the laboratory mouse (Mus musculus). Lab Anim. 2007; 41(1):92-102. DOI: 10.1258/002367707779399482. View

11.

Armstrong K, Clark T, Peterson M . Use of Corn-Husk Nesting Material to Reduce Aggression in Caged Mice. Contemp Top Lab Anim Sci. 2002; 37(4):64-66. View

12.

Powell S, Newman H, McDonald T, Bugenhagen P, Lewis M . Development of spontaneous stereotyped behavior in deer mice: effects of early and late exposure to a more complex environment. Dev Psychobiol. 2000; 37(2):100-8. View

13.

Marashi V, Barnekow A, Sachser N . Effects of environmental enrichment on males of a docile inbred strain of mice. Physiol Behav. 2004; 82(5):765-76. DOI: 10.1016/j.physbeh.2004.05.009. View

14.

Bezard E, Dovero S, Belin D, Duconger S, Jackson-Lewis V, Przedborski S . Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors. J Neurosci. 2003; 23(35):10999-1007. PMC: 6741042. View

15.

Smith G, Hoffman W, Lee E, YOUNG J . Improving the environment of mice by using synthetic gauze pads. Contemp Top Lab Anim Sci. 2001; 39(6):51-3. View

16.

Wright-Williams S, Courade J, Richardson C, Roughan J, Flecknell P . Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse. Pain. 2007; 130(1-2):108-18. DOI: 10.1016/j.pain.2006.11.003. View

17.

Hutchinson E, Avery A, VandeWoude S . Environmental enrichment for laboratory rodents. ILAR J. 2005; 46(2):148-61. DOI: 10.1093/ilar.46.2.148. View

18.

Karas A . Postoperative analgesia in the laboratory mouse, Mus musculus. Lab Anim (NY). 2002; 31(7):49-52. DOI: 10.1038/5000175. View

19.

Beauquis J, Roig P, De Nicola A, Saravia F . Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice. PLoS One. 2010; 5(11):e13993. PMC: 2981567. DOI: 10.1371/journal.pone.0013993. View

20.

Lazarov O, Robinson J, Tang Y, Hairston I, Korade-Mirnics Z, Lee V . Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 2005; 120(5):701-13. DOI: 10.1016/j.cell.2005.01.015. View