Prediction of Renal Allograft Chronic Rejection Using a Model Based on Contrast-enhanced Ultrasonography

Overview

Journal Microcirculation

Specialties Biology
Cardiology & Vascular Diseases

Date 2019 Mar 20

PMID 30887637

Citations 11

Authors

Cheng Yang

Shengdi Wu

Ping Yang

Guoguo Shang

Ruochen Qi

Ming Xu

Ruiming Rong

Tongyu Zhu

Wanyuan He

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the application of contrast-enhanced ultrasonography (CEUS) for the diagnosis of renal allograft chronic rejection (CR).

Methods: A total of 104 patients who were suspected to have AR or CR were enrolled in this study (derivation group, n = 66; validation group, n = 38). Before biopsy, all patients received an ultrasound examination.

Results: In the CR group, rising time (RT) and time to peak (TTP) of medulla (RTm and TTPm, respectively) were significantly longer compared to those in the AR group. The kidney volume was significantly decreased in the CR group but was increased in the AR group. In the derivation group, age, change in kidney volume, and TTPm were identified as independent predictors by multivariate analysis. Based on the multivariate analysis results and area under receiver operating characteristic (ROC) curves (AUROCs) of individual markers, we constructed a new index as follows: P = -5.424 + 0.074 × age -9.818 × kidney volume change + 0.115 × TTPm; New Index = e /(1 + e ). The new index discriminates CR from AR and had better AUROCs than any other parameters.

Conclusion: In conclusion, the new index provides a new diagnosis model for CR.

Citing Articles

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Friedl S, Jung E, Bergler T, Tews H, Banas M, Banas B Front Med (Lausanne). 2022; 9:928567.

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