Enhanced Cortical Bone Expansion in -deficient Mice During Aging

Overview

Journal Bone Res

Specialties Endocrinology
Orthopedics

Date 2019 Mar 20

PMID 30886760

Citations 6

Authors

Kevin A Maupin

Kevin Weaver

Alexis Bergsma

Cheryl Christie

Zhendong A Zhong

Tao Yang

Bart O Williams

Affiliations

Soon will be listed here.

Abstract

Imbalances between bone formation and bone resorption, which can occur due to aging or sex hormone deprivation, result in decreased bone mass and an increased risk of fracture. Previous studies have suggested that the β-galactoside binding lectin, galectin-3, is involved in bone remodeling. We compared bone parameters of mice having null alleles of the galectin-3 gene (-KO) with those of their wild-type littermates. deficiency increased cortical bone expansion at 36 weeks (wk) and preserved or enhanced bone mass in both male and female mutant mice. In addition, female -KO mice were protected from age-related loss of trabecular bone. Histomorphometry and ex vivo primary cell differentiation assays showed increased osteoblastogenesis with little-to-no effect on osteoclastogenesis, suggesting the increased bone mass phenotype is primarily due to increased anabolism. Our study identifies galectin-3 as a negative regulator of bone formation and suggests that disruption of galectin-3 may be useful in preventing bone loss during aging.

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