MIR100HG: a Credible Prognostic Biomarker and an Oncogenic LncRNA in Gastric Cancer

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2019 Mar 20

PMID 30886062

Citations 27

Authors

Jun Li

Qingfeng Xu

Wen Wang

Shaojun Sun

Affiliations

Soon will be listed here.

Abstract

The MIR100HG expression was observed to be up-regulated or down-regulated in human cancer tissues depending on tumor types. However, there was no report about the role of MIR100HG in gastric cancer. In our study, we first found levels of MIR100HG expression were increased in gastric cancer cell lines and tissue samples compared with normal gastric epithelial cell line and adjacent normal gastric mucosa tissue samples, respectively. Moreover, high MIR100HG expression was positively associated with clinical stage, tumor invasion, lymph node metastasis, and distant metastasis in gastric cancer patients. Survival analysis showed MIR100HG expression was negative correlated with clinical outcome in gastric cancer patients from The Cancer Genome Atlas (TCGA) database or our study, and high MIR100HG expression served as an independent poor prognostic factor for gastric cancer patient's overall survival. The study suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. In conclusion, MIR100HG is a credible prognostic biomarker and functions as an oncogenic lncRNA in gastric cancer.

Citing Articles

Identification of modules and key genes associated with breast cancer subtypes through network analysis.

Mares-Quinones M, Galan-Vasquez E, Perez-Rueda E, Perez-Ishiwara D, Medel-Flores M, Gomez-Garcia M Sci Rep. 2024; 14(1):12350.

PMID: 38811600 PMC: 11137066. DOI: 10.1038/s41598-024-61908-4.

Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4.

Guo M, Hu P, Xie J, Tang K, Hu S, Sun J Genes Dis. 2024; 11(4):101164.

PMID: 38560505 PMC: 10980949. DOI: 10.1016/j.gendis.2023.101164.

LncRNA MIR100HG Promotes Cell Proliferation in Nasopharyngeal Carcinoma by Targeting miR-136-5p/IL-6 Axis.

Huang X, Zhong H, Cai Y Mol Biotechnol. 2024; 66(5):1279-1289.

PMID: 38278928 DOI: 10.1007/s12033-023-01028-y.

A concise review on the role of MIR100HG in human disorders.

Ghafouri-Fard S, Harsij A, Farahzadi H, Hussen B, Taheri M, Mokhtari M J Cell Mol Med. 2023; 27(16):2278-2289.

PMID: 37487022 PMC: 10424294. DOI: 10.1111/jcmm.17875.

A cuproptosis-related LncRNA signature: Integrated analysis associated with biochemical recurrence and immune landscape in prostate cancer.

Ren L, Yang X, Wang W, Lin H, Huang G, Liu Z Front Genet. 2023; 14:1096783.

PMID: 36911392 PMC: 9999016. DOI: 10.3389/fgene.2023.1096783.

References

Togasaki K, Sukawa Y, Kanai T, Takaishi H . Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: an evidence-based review of therapies. Onco Targets Ther. 2018; 11:8239-8250. PMC: 6254591. DOI: 10.2147/OTT.S152514. View

Wang S, Ke H, Zhang H, Ma Y, Ao L, Zou L . LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death Dis. 2018; 9(8):805. PMC: 6057987. DOI: 10.1038/s41419-018-0869-2. View

Su X, Teng J, Jin G, Li J, Zhao Z, Cao X . ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2. Biomed Pharmacother. 2018; 109:788-797. DOI: 10.1016/j.biopha.2018.10.029. View

Zurleni T, Gjoni E, Altomare M, Rausei S . Conversion surgery for gastric cancer patients: A review. World J Gastrointest Oncol. 2018; 10(11):398-409. PMC: 6247102. DOI: 10.4251/wjgo.v10.i11.398. View

Shang C, Zhu W, Liu T, Wang W, Huang G, Huang J . Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncol Rep. 2016; 35(6):3185-97. PMC: 4869942. DOI: 10.3892/or.2016.4715. View

Ng S, Johnson R, Stanton L . Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J. 2011; 31(3):522-33. PMC: 3273385. DOI: 10.1038/emboj.2011.459. View

Ding B, Lou W, Xu L, Fan W . Non-coding RNA in drug resistance of hepatocellular carcinoma. Biosci Rep. 2018; 38(5). PMC: 6177555. DOI: 10.1042/BSR20180915. View

Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J . miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet. 2014; 10(2):e1004177. PMC: 3937226. DOI: 10.1371/journal.pgen.1004177. View

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

10.

Imanishi T, Itoh T, Suzuki Y, ODonovan C, Fukuchi S, Koyanagi K . Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol. 2004; 2(6):e162. PMC: 393292. DOI: 10.1371/journal.pbio.0020162. View

11.

Lu Y, Zhao X, Liu Q, Li C, Graves-Deal R, Cao Z . lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling. Nat Med. 2017; 23(11):1331-1341. PMC: 5961502. DOI: 10.1038/nm.4424. View

12.

Yang Y, Peng X . The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through the ATM-E2F1 signaling pathway. Biosci Rep. 2018; 38(6). PMC: 6294646. DOI: 10.1042/BSR20180558. View

13.

Wilkins O, Titus A, Salas L, Gui J, Eliot M, Butler R . MicroRNA-Related Genetic Variants Associated with Survival of Head and Neck Squamous Cell Carcinoma. Cancer Epidemiol Biomarkers Prev. 2018; 28(1):127-136. PMC: 6286226. DOI: 10.1158/1055-9965.EPI-18-0002. View

14.

Song H, Xu Y, Shi L, Xu T, Fan R, Cao M . LncRNA THOR increases the stemness of gastric cancer cells via enhancing SOX9 mRNA stability. Biomed Pharmacother. 2018; 108:338-346. DOI: 10.1016/j.biopha.2018.09.057. View

15.

Emmrich S, Streltsov A, Schmidt F, Thangapandi V, Reinhardt D, Klusmann J . LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia. Mol Cancer. 2014; 13:171. PMC: 4118279. DOI: 10.1186/1476-4598-13-171. View

16.

de Oliveira J, Oliveira L, Mathias C, Pedroso G, Lemos D, Salviano-Silva A . Long non-coding RNAs in cancer: Another layer of complexity. J Gene Med. 2018; 21(1):e3065. DOI: 10.1002/jgm.3065. View

17.

Wang R, Li J, Zhao Y, Li Y, Yin L . Investigating the therapeutic potential and mechanism of curcumin in breast cancer based on RNA sequencing and bioinformatics analysis. Breast Cancer. 2017; 25(2):206-212. DOI: 10.1007/s12282-017-0816-6. View

18.

Zhang Y, Yu S, Zhang Z, Zhao G, Xu J . Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression. Biosci Rep. 2018; 38(4). PMC: 6050193. DOI: 10.1042/BSR20180277. View

19.

Matsuoka T, Yashiro M . Biomarkers of gastric cancer: Current topics and future perspective. World J Gastroenterol. 2018; 24(26):2818-2832. PMC: 6048430. DOI: 10.3748/wjg.v24.i26.2818. View

20.

Mathias C, Zambalde E, Rask P, Gradia D, de Oliveira J . Long non-coding RNAs differential expression in breast cancer subtypes: What do we know?. Clin Genet. 2019; 95(5):558-568. DOI: 10.1111/cge.13502. View