The Second Genome: Effects of the Mitochondrial Genome on Cancer Progression

Overview

Journal Adv Cancer Res

Publisher Elsevier

Specialty Oncology

Date 2019 Mar 20

PMID 30885364

Citations 11

Authors

Adam D Scheid

Thomas C Beadnell

Danny R Welch

Affiliations

Soon will be listed here.

Abstract

The role of genetics in cancer has been recognized for centuries, but most studies elucidating genetic contributions to cancer have understandably focused on the nuclear genome. Mitochondrial contributions to cancer pathogenesis have been documented for decades, but how mitochondrial DNA (mtDNA) influences cancer progression and metastasis remains poorly understood. This lack of understanding stems from difficulty isolating the nuclear and mitochondrial genomes as experimental variables, which is critical for investigating direct mtDNA contributions to disease given extensive crosstalk exists between both genomes. Several in vitro and in vivo models have isolated mtDNA as an independent variable from the nuclear genome. This review compares and contrasts different models, their advantages and disadvantages for studying mtDNA contributions to cancer, focusing on the mitochondrial-nuclear exchange (MNX) mouse model and findings regarding tumor progression, metastasis, and other complex cancer-related phenotypes.

Citing Articles

A Customized Human Mitochondrial DNA Database (hMITO DB v1.0) for Rapid Sequence Analysis, Haplotyping and Geo-Mapping.

Shen-Gunther J, Gunther R, Cai H, Wang Y Int J Mol Sci. 2023; 24(17).

PMID: 37686313 PMC: 10488239. DOI: 10.3390/ijms241713505.

Next-generation sequencing reveals mitogenome diversity in plasma extracellular vesicles from colorectal cancer patients.

Bjornetro T, Bousquet P, Redalen K, Troseid A, Luders T, Stang E BMC Cancer. 2023; 23(1):650.

PMID: 37438741 PMC: 10337118. DOI: 10.1186/s12885-023-11092-x.

Analysis of Mitochondrial Transfer RNA Mutations in Breast Cancer.

Ding H, Zhao Y, Jiang Z, Zhou D, Zhu R Balkan J Med Genet. 2023; 25(2):15-22.

PMID: 37265965 PMC: 10230833. DOI: 10.2478/bjmg-2022-0020.

Generating Mitochondrial-Nuclear Exchange (MNX) Mice to Identify Mitochondrial Determinants of Cancer Metastasis.

Welch D, Larson M, Vivian C, Vivian J Methods Mol Biol. 2023; 2660:43-59.

PMID: 37191789 PMC: 10195030. DOI: 10.1007/978-1-0716-3163-8_4.

Roles of mitochondrial genetics in cancer metastasis.

Welch D, Foster C, Rigoutsos I Trends Cancer. 2022; 8(12):1002-1018.

PMID: 35915015 PMC: 9884503. DOI: 10.1016/j.trecan.2022.07.004.

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