MirtronDB: a Mirtron Knowledge Base
Overview
Affiliations
Motivation: Mirtrons arise from short introns with atypical cleavage by using the splicing mechanism. In the current literature, there is no repository centralizing and organizing the data available to the public. To fill this gap, we developed mirtronDB, the first knowledge database dedicated to mirtron, and it is available at http://mirtrondb.cp.utfpr.edu.br/. MirtronDB currently contains a total of 1407 mirtron precursors and 2426 mirtron mature sequences in 18 species.
Results: Through a user-friendly interface, users can now browse and search mirtrons by organism, organism group, type and name. MirtronDB is a specialized resource that provides free and user-friendly access to knowledge on mirtron data.
Availability And Implementation: MirtronDB is available at http://mirtrondb.cp.utfpr.edu.br/.
Supplementary Information: Supplementary data are available at Bioinformatics online.
tRNA, yRNA, and rRNA fragment excisions do not involve canonical microRNA biogenesis machinery.
Godang N, Nguyen A, DeMeis J, Paudel S, Campbell N, Barnes K MicroPubl Biol. 2024; 2024.
PMID: 39634108 PMC: 11615671. DOI: 10.17912/micropub.biology.001332.
A tailed mirtron promotes longevity in Drosophila.
Khanal S, de Cruz M, Strickland B, Mansfield K, Lai E, Flynt A Nucleic Acids Res. 2023; 52(3):1080-1089.
PMID: 38048325 PMC: 10853799. DOI: 10.1093/nar/gkad1158.
Playfoot C, Sheppard S, Planet E, Trono D RNA. 2022; 28(9):1157-1171.
PMID: 35732404 PMC: 9380744. DOI: 10.1261/rna.079100.122.
Predicting Drosha and Dicer Cleavage Sites with DeepMirCut.
Bell J, Hendrix D Front Mol Biosci. 2022; 8:799056.
PMID: 35141278 PMC: 8819831. DOI: 10.3389/fmolb.2021.799056.
de Amorim T, Pedro D, Paschoal A Methods Mol Biol. 2021; 2257:131-166.
PMID: 34432277 DOI: 10.1007/978-1-0716-1170-8_7.