Hypoxia and the Regulation of Myeloid Cell Metabolic Imprinting: Consequences for the Inflammatory Response

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2019 Mar 16

PMID 30872317

Citations 35

Authors

Pranvera Sadiku

Sarah R Walmsley

Affiliations

Soon will be listed here.

Abstract

Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of transcription factors known as hypoxia-inducible factors (HIFs). The protein members of the HIF signalling pathway are critical regulators of both the innate and adaptive immune responses, and there is an increasing body of evidence to suggest that the elicited changes occur through cellular metabolic reprogramming. Here, we review the literature on innate immunometabolism to date and discuss the role of hypoxia in innate cell metabolic reprogramming, and how this determines immune responses.

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