Transport of Proteins into Mitochondria

Overview

Journal Protein J

Publisher Springer

Specialty Biochemistry

Date 2019 Mar 15

PMID 30868341

Citations 74

Authors

Katja G Hansen

Johannes M Herrmann

Affiliations

Soon will be listed here.

Abstract

Mitochondria are essential organelles of eukaryotic cells. They consist of hundreds of different proteins that exhibit crucial activities in respiration, catabolic metabolism and the synthesis of amino acids, lipids, heme and iron-sulfur clusters. With the exception of a handful of hydrophobic mitochondrially encoded membrane proteins, all these proteins are synthesized on cytosolic ribosomes, targeted to receptors on the mitochondrial surface, and transported across or inserted into the outer and inner mitochondrial membrane before they are folded and assembled into their final native structure. This review article provides a comprehensive overview of the mechanisms and components of the mitochondrial protein import systems with a particular focus on recent developments in the field.

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