Organelle Interplay-peroxisome Interactions in Health and Disease

Overview

Journal J Inherit Metab Dis

Publisher Wiley

Date 2019 Mar 14

PMID 30864148

Citations 54

Authors

Michael Schrader

Maki Kamoshita

Markus Islinger

Affiliations

Soon will be listed here.

Abstract

Peroxisomes are multifunctional, dynamic, membrane-bound organelles with important functions in cellular lipid metabolism, rendering them essential for human health and development. Important roles for peroxisomes in signaling and the fine-tuning of cellular processes are emerging, which integrate them in a complex network of interacting cellular compartments. Like many other organelles, peroxisomes communicate through membrane contact sites. For example, peroxisomal growth, positioning, and lipid metabolism involves contacts with the endoplasmic reticulum (ER). Here, we discuss the most recent findings on peroxisome-organelle interactions including peroxisome-ER interplay at membrane contacts sites, and functional interplay with mitochondria, lysosomes, and lipid droplets in mammalian cells. We address tether proteins, metabolic cooperation, and the impact of peroxisome interactions on human health and disease.

Citing Articles

Peroxisomal core structures segregate diverse metabolic pathways.

Backer N, Ast J, Martorana D, Renicke C, Berger J, Mais C Nat Commun. 2025; 16(1):1802.

PMID: 39979331 PMC: 11842775. DOI: 10.1038/s41467-025-57053-9.

PEX1 remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome.

Sheedy C, Chowdhury S, Ali B, Miyamoto J, Pang E, Bacal J bioRxiv. 2024; .

PMID: 39713301 PMC: 11661142. DOI: 10.1101/2024.12.10.627778.

Distinct peroxisome populations differentially respond to alcohol-associated hepatic injury.

Mitra R, Adhikari R, Davis S, McVicker B, Tuma P Mol Biol Cell. 2024; 35(12):ar156.

PMID: 39535899 PMC: 11656475. DOI: 10.1091/mbc.E24-06-0252.

Targeting catalase in cancer.

Glorieux C, Buc Calderon P Redox Biol. 2024; 77:103404.

PMID: 39447253 PMC: 11539659. DOI: 10.1016/j.redox.2024.103404.

The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.

Montes I, Amirthagunanathan S, Joshi A, Raman M bioRxiv. 2024; .

PMID: 39386596 PMC: 11463529. DOI: 10.1101/2024.09.24.614749.

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