Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Overview

Journal Adv Funct Mater

Date 2019 Mar 12

PMID 30853878

Citations 21

Authors

Anil Kumar

Aaron Tan

Joanna Wong

Jonathan Clayton Spagnoli

James Lam

Brianna Diane Blevins

Natasha G

Lewis Thorne

Keyoumars Ashkan

Jin Xie

Hong Liu

Affiliations

Soon will be listed here.

Abstract

Unlocking the secrets of the brain is a task fraught with complexity and challenge - not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. The evolution of ever more sophisticated nanomaterials culminates in network-operant functionalized agents. In turn, these materials contribute to novel diagnostic and therapeutic strategies, including drug delivery, neuroprotection, neural regeneration, neuroimaging and neurosurgery. Further, the entrance of nanotechnology into future research arenas including optogenetics, molecular/ion sensing and monitoring, and piezoelectric effects is discussed. Finally, considerations in nanoneurotoxicity, the main barrier to clinical translation, are reviewed, and direction for future perspectives is provided.

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References

Ghasemi-Mobarakeh L, Prabhakaran M, Morshed M, Nasr-Esfahani M, Baharvand H, Kiani S . Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. J Tissue Eng Regen Med. 2011; 5(4):e17-35. DOI: 10.1002/term.383. View

Shi N, Zhang Y, Zhu C, Boado R, Pardridge W . Brain-specific expression of an exogenous gene after i.v. administration. Proc Natl Acad Sci U S A. 2001; 98(22):12754-9. PMC: 60126. DOI: 10.1073/pnas.221450098. View

Rossmeisl Jr J, Garcia P, Pancotto T, Robertson J, Henao-Guerrero N, Neal 2nd R . Safety and feasibility of the NanoKnife system for irreversible electroporation ablative treatment of canine spontaneous intracranial gliomas. J Neurosurg. 2015; 123(4):1008-25. DOI: 10.3171/2014.12.JNS141768. View

Wen J, Liu M . Piezoelectric ceramic (PZT) modulates axonal guidance growth of rat cortical neurons via RhoA, Rac1, and Cdc42 pathways. J Mol Neurosci. 2013; 52(3):323-30. DOI: 10.1007/s12031-013-0149-7. View

Marsh M, Koehne J, Andrews R, Meyyappan M, Bennet K, Lee K . Carbon nanofiber multiplexed array and Wireless Instantaneous Neurotransmitter Concentration Sensor for simultaneous detection of dissolved oxygen and dopamine. Biomed Eng Lett. 2014; 2(4):271-277. PMC: 3969753. DOI: 10.1007/s13534-012-0081-8. View

Bernstein J, Garrity P, Boyden E . Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits. Curr Opin Neurobiol. 2011; 22(1):61-71. PMC: 3292652. DOI: 10.1016/j.conb.2011.10.023. View

Wilson B, Samanta M, Santhi K, Sampath Kumar K, Ramasamy M, Suresh B . Significant delivery of tacrine into the brain using magnetic chitosan microparticles for treating Alzheimer's disease. J Neurosci Methods. 2008; 177(2):427-33. DOI: 10.1016/j.jneumeth.2008.10.036. View

Cornelius C, Crupi R, Calabrese V, Graziano A, Milone P, Pennisi G . Traumatic brain injury: oxidative stress and neuroprotection. Antioxid Redox Signal. 2013; 19(8):836-53. DOI: 10.1089/ars.2012.4981. View

Vu T, Maddipati R, Blute T, Nehilla B, Nusblat L, Desai T . Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth. Nano Lett. 2005; 5(4):603-7. DOI: 10.1021/nl047977c. View

10.

Das S, Carnicer-Lombarte A, Fawcett J, Bora U . Bio-inspired nano tools for neuroscience. Prog Neurobiol. 2016; 142:1-22. DOI: 10.1016/j.pneurobio.2016.04.008. View

11.

Oller-Salvia B, Sanchez-Navarro M, Giralt E, Teixido M . Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery. Chem Soc Rev. 2016; 45(17):4690-707. DOI: 10.1039/c6cs00076b. View

12.

Veiseh O, Gunn J, Zhang M . Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2009; 62(3):284-304. PMC: 2827645. DOI: 10.1016/j.addr.2009.11.002. View

13.

Zhu J, Zhou L, XingWu F . Tracking neural stem cells in patients with brain trauma. N Engl J Med. 2006; 355(22):2376-8. DOI: 10.1056/NEJMc055304. View

14.

Smith A, Nie S . Semiconductor nanocrystals: structure, properties, and band gap engineering. Acc Chem Res. 2009; 43(2):190-200. PMC: 2858563. DOI: 10.1021/ar9001069. View

15.

Spindler M, Beal M, Henchcliffe C . Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatr Dis Treat. 2009; 5:597-610. PMC: 2785862. DOI: 10.2147/ndt.s5212. View

16.

Zhang D, Rand E, Marsh M, Andrews R, Lee K, Meyyappan M . Carbon nanofiber electrode for neurochemical monitoring. Mol Neurobiol. 2013; 48(2):380-5. PMC: 3932670. DOI: 10.1007/s12035-013-8531-6. View

17.

Azadi A, Hamidi M, Rouini M . Methotrexate-loaded chitosan nanogels as 'Trojan Horses' for drug delivery to brain: preparation and in vitro/in vivo characterization. Int J Biol Macromol. 2013; 62:523-30. DOI: 10.1016/j.ijbiomac.2013.10.004. View

18.

Helmus M . The need for rules and regulations. Nat Nanotechnol. 2008; 2(6):333-4. DOI: 10.1038/nnano.2007.165. View

19.

Engels M, Bilgic E, Pinto A, Vasquez E, Wollschlager L, Steinbrenner H . A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage. J Inflamm (Lond). 2014; 11:26. PMC: 4231204. DOI: 10.1186/s12950-014-0026-3. View

20.

Li N, Zhang X, Song Q, Su R, Zhang Q, Kong T . The promotion of neurite sprouting and outgrowth of mouse hippocampal cells in culture by graphene substrates. Biomaterials. 2011; 32(35):9374-82. DOI: 10.1016/j.biomaterials.2011.08.065. View