ΔNp63 in Squamous Cell Carcinoma: Defining the Oncogenic Routes Affecting Epigenetic Landscape and Tumour Microenvironment

Overview

Journal Mol Oncol

Specialties Molecular Biology
Oncology

Date 2019 Mar 8

PMID 30845357

Citations 48

Authors

Veronica Gatti

Claudia Fierro

Margherita Annicchiarico-Petruzzelli

Gerry Melino

Angelo Peschiaroli

Affiliations

Soon will be listed here.

Abstract

Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in SCC of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro-tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying ΔNp63 oncogenic activities in SCC, and discuss some relevant transcriptional effectors of ΔNp63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (TME).

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