Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project

Overview

Journal J Atheroscler Thromb

Date 2019 Mar 8

PMID 30842389

Citations 6

Authors

Enric Sanchez

Angels Betriu

Andree Yeramian

Elvira Fernandez

Francesc Purroy

Manuel Sanchez-de-la-Torre

Reinald Pamplona

Eva Miquel

Mohsen Kerkeni

Cristina Hernandez

Rafael Simo

Albert Lecube

Marta Hernandez

Ferran Rius

Dinora Polanco

Ferran Barbe

Gerard Torres

Guillermo Suarez

Manuel Portero-Otin

Mariona Jove

Laura Colas-Campas

Ikram Benabdelhak

Cristina Farras

Marta Ortega

Jose Manuel Valdivielso

Marcelino Bermudez-Lopez

Montse Martinez-Alonso

Affiliations

Soon will be listed here.

Abstract

Aim: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk.

Methods: A cross-sectional study in which 2,568 non-diabetic subjects of both sexes without cardiovascular disease were included. Subcutaneous content of AGEs was assessed by skin autofluorescence (SAF) and subclinical atheromatous disease was measured by assessing the atheromatous plaque burden in carotid and femoral regions using ultrasonography. In addition, serum pentosidine, carboxymethyl-lysine (CML) and AGE receptors (RAGE) were assessed in a nested case-control study with 41 subjects without plaque and 41 individuals subjects with generalized disease.

Results: Patients with atheromatous plaque had a higher SAF than those with no plaque (1.9 [1.7 to 2.3] vs. 1.8 [1.6 to 2.1] arbitrary units (AU), p＜0.001). The SAF correlated with the total number of affected regions (r= 0.171, p＜0.001), increasing progressively from 1.8 [1.6 to 2.1] AU in those without atheromatous disease to 2.3 [1.9 to 2.7] AU in patients with ≥ 8 plaques (p＜0.001). A correlation was also observed between SAF and the total plaque area (r=0.113, p＜0.001). The area under the Receiver Operating Characteristic curve was 0.65 (0.61 to 0.68) for identifying male subjects with atheromatous disease. The multivariable logistic regression model showed a significant and independent association between SAF and the presence of atheromatous disease. However, no significant differences in serum pentosidine, CML, and RAGE were observed.

Conclusions: Increased subcutaneous content of AGEs is associated with augmented atheromatous plaque burden. Our results suggest that SAF may provide clinically relevant information to the current strategies for the evaluation of cardiovascular risk, especially among the male population.

Citing Articles

Advanced Glycation Endproducts: A Marker of Long-term Exposure to Glycemia.

Klonoff D, Aaron R, Tian T, DuNova A, Pandey A, Rhee C J Diabetes Sci Technol. 2024; :19322968241240436.

PMID: 38525944 PMC: 11572222. DOI: 10.1177/19322968241240436.

Skin Autofluorescence and Clinical Outcomes in Patients with Coronary Artery Disease.

Kawamoto H, Hanatani S, Tsujita K, Ruparelia N, Chou S, Kono Y J Atheroscler Thromb. 2023; 31(3):316-325.

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Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project.

Sanchez E, Sanchez M, Lopez-Cano C, Bermudez-Lopez M, Valdivielso J, Farras-Salles C Nutrients. 2023; 15(1).

PMID: 36615860 PMC: 9824455. DOI: 10.3390/nu15010203.

Advanced Glycations End Products in the Skin as Biomarkers of Cardiovascular Risk in Type 2 Diabetes.

Planas A, Simo-Servat O, Hernandez C, Simo R Int J Mol Sci. 2022; 23(11).

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Advanced Glycation End Products: A Sweet Flavor That Embitters Cardiovascular Disease.

Pinto R, Minanni C, de Araujo Lira A, Passarelli M Int J Mol Sci. 2022; 23(5).

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