VEGF, VEGF165b and EG-VEGF Expression is Specifically Related with Hormone Profile in Pituitary Adenomas

Overview

Journal Eur J Histochem

Specialty Biochemistry

Date 2019 Mar 7

PMID 30838843

Citations 8

Authors

Ana Silvia Corlan

Anca Maria Cimpean

Eugen Melnic

Marius Raica

Simona Sarb

Affiliations

Soon will be listed here.

Abstract

Vascular endothelial growth factor (VEGF), its inhibitory splice variant, VEGF165b and Endocrine Gland derived VEGF (EG-VEGF) have a controversial role in pituitary gland. We aim to study VEGF, VEGF165b and EG-VEGF expression in pituitary adenomas. A significant correlation was found between growth hormone (GH) and VEGF secretion (P=0.024). For prolactinomas, VEGF and prolactin expression, had a P-value of 0.02 for Kendall coefficient and a P-value of 0.043 for the Spearman coefficient. VEGF-mRNA amplification was detected in both tumor cells and folliculostellate cells. VEGF165b was positive in 16.66% of pituitary adenomas. EG-VEGF was significantly correlated with prolactin (P=0.025) and luteinizing hormone (P=0.028). Our data strongly support VEGF, VEGF165b and EG-VEGF as important players of pituitary adenomas tumorigenesis. Particular hormonal milieu heterogeneity, special vascular network with an unusual reactivity to tumor growth correlated with variability of VEGF, VEGF165b and EG-VEGF secretion may stratify pituitary adenomas in several molecular groups with a direct impact on therapy and prognosis.

Citing Articles

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The biological behavior and clinical outcome of pituitary adenoma are affected by the microenvironment.

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Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches.

Han C, Lin S, Lu X, Xue L, Wu Z Front Endocrinol (Lausanne). 2021; 12:785050.

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