Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Cancer Development and Tumor Angiogenesis

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2017 Apr 8

PMID 28386275

Citations 9

Authors

Ana Silvia Corlan

Anca Maria Cimpean

Adriana-Andreea Jitariu

Eugen Melnic

Marius Raica

Affiliations

Soon will be listed here.

Abstract

A lot of data suggests endocrine gland-derived vascular endothelial growth factor (EG-VEGF) to be restricted to endocrine glands and to some endocrine-dependent organs. Many evidences show that EG-VEGF stimulates angiogenesis and cell proliferation, although it is not a member of the VEGF family. At the time, a lot of data regarding the role of this growth factor in normal development are available. However, controversial results have been published in the case of pathological conditions and particularly in malignant tumors. Thus, our present paper has been focused on the role of EG-VEGF in normal tissues and various malignant tumors and their angiogenic processes.

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