Regulation of Immune Responses by I-J Gene Products. VI. Recognition of I-E Molecules by I-J-bearing Suppressor Factors

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1986 Apr 1

PMID 3081680

Citations 6

Authors

C Waltenbaugh

L Sun

H Y Lei

Affiliations

Soon will be listed here.

Abstract

Poly(Glu50Tyr50) (GT) is not immunogenic in most inbred mouse strains. GT injection produces an I-J--bearing, GT-specific T-cell--derived suppressor factor (GT-TsF1) in H-2b,d,k haplotype mice. GT-TsF1 generates second-order suppressor T cells (Ts2) in H-2a,d,k haplotype mice. Here, we show that in order for GT-TsF1 to act, the recipient strain must express I-E molecules. This suggests that T cells are not the primary target of GT-TsF1. GT-TsF1 can be presented by Ia+ A20-2J B lymphoma cells. GT-TsF1 presentation is blocked by anti-I-E, but not by anti--I-A, mAb, whereas GAT presentation is blocked by anti-I-A, but not by anti--I-E, mAbs. These data suggest that I-J recognizes (or is recognized by) I-E. The existence and role of I-J molecules in immune regulation are discussed in light of these data.

Citing Articles

Suppressor T cells, antigen-presenting cells and the role of I-J restriction in oral tolerance to ovalbumin.

Mowat A, Lamont A, Parrott D Immunology. 1988; 64(1):141-5.

PMID: 2968305 PMC: 1385199.

Induction of contrasuppression is restricted by genes mapping to the IgH locus.

Green D, Chue B, Flood P Immunol Res. 1988; 7(1):82-92.

PMID: 2897413 DOI: 10.1007/BF02918156.

Immune suppression genes.

Oliveira D, Mitchison N Clin Exp Immunol. 1989; 75(2):167-77.

PMID: 2467772 PMC: 1542112.

Altered I-J phenotype in E alpha transgenic mice.

Flood P, Benoist C, Mathis D, Murphy D Proc Natl Acad Sci U S A. 1986; 83(21):8308-12.

PMID: 2430283 PMC: 386917. DOI: 10.1073/pnas.83.21.8308.

A murine macrophage line of the H-2d/f haplotype can activate H-2k suppressor T cells.

Chang M, Jaureguiberry B, Garrido E, Diamond B Proc Natl Acad Sci U S A. 1990; 87(7):2501-5.

PMID: 2138779 PMC: 53717. DOI: 10.1073/pnas.87.7.2501.

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