Ionic Liquids As Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2019 Mar 1

PMID 30813375

Citations 29

Authors

Zainul Sidat

Thashree Marimuthu

Pradeep Kumar

Lisa C du Toit

Pierre P D Kondiah

Yahya E Choonara

Viness Pillay

Affiliations

Soon will be listed here.

Abstract

Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed.

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