Gametogenesis: A Journey from Inception to Conception

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2019 Feb 25

PMID 30797511

Citations 38

Authors

Hailey Larose

Adrienne Niederriter Shami

Haley Abbott

Gabriel Manske

Lei Lei

Saher Sue Hammoud

Affiliations

Soon will be listed here.

Abstract

Gametogenesis, the process of forming mature germ cells, is an integral part of both an individual's and a species' health and well-being. This chapter focuses on critical male and female genetic and epigenetic processes underlying normal gamete formation through their differentiation to fertilization. Finally, we explore how knowledge gained from this field has contributed to progress in areas with great clinical promise, such as in vitro gametogenesis.

Citing Articles

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References

Molyneaux K, Zinszner H, Kunwar P, Schaible K, Stebler J, Sunshine M . The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development. 2003; 130(18):4279-86. DOI: 10.1242/dev.00640. View

Suzuki H, Sada A, Yoshida S, Saga Y . The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol. 2009; 336(2):222-31. DOI: 10.1016/j.ydbio.2009.10.002. View

Lee J, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S . Akt mediates self-renewal division of mouse spermatogonial stem cells. Development. 2007; 134(10):1853-9. DOI: 10.1242/dev.003004. View

Clifton D, Bremner W . The effect of testicular x-irradiation on spermatogenesis in man. A comparison with the mouse. J Androl. 1983; 4(6):387-92. DOI: 10.1002/j.1939-4640.1983.tb00765.x. View

Kota S, Feil R . Epigenetic transitions in germ cell development and meiosis. Dev Cell. 2010; 19(5):675-86. DOI: 10.1016/j.devcel.2010.10.009. View

Parvanov E, Petkov P, Paigen K . Prdm9 controls activation of mammalian recombination hotspots. Science. 2010; 327(5967):835. PMC: 2821451. DOI: 10.1126/science.1181495. View

Simorangkir D, Marshall G, Plant T . A re-examination of proliferation and differentiation of type A spermatogonia in the adult rhesus monkey (Macaca mulatta). Hum Reprod. 2009; 24(7):1596-604. PMC: 2698324. DOI: 10.1093/humrep/dep051. View

Blume-Jensen P, Jiang G, HYMAN R, Lee K, OGorman S, Hunter T . Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. Nat Genet. 2000; 24(2):157-62. DOI: 10.1038/72814. View

Koopman P, Gubbay J, Vivian N, Goodfellow P, Lovell-Badge R . Male development of chromosomally female mice transgenic for Sry. Nature. 1991; 351(6322):117-21. DOI: 10.1038/351117a0. View

10.

Tremblay K, Dunn N, Robertson E . Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001; 128(18):3609-21. DOI: 10.1242/dev.128.18.3609. View

11.

Gong F, Miller K . Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation. Mutat Res. 2013; 750(1-2):23-30. DOI: 10.1016/j.mrfmmm.2013.07.002. View

12.

Miyamoto N, Yoshida M, Kuratani S, Matsuo I, Aizawa S . Defects of urogenital development in mice lacking Emx2. Development. 1997; 124(9):1653-64. DOI: 10.1242/dev.124.9.1653. View

13.

Yoshida S, Takakura A, Ohbo K, Abe K, Wakabayashi J, Yamamoto M . Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol. 2004; 269(2):447-58. DOI: 10.1016/j.ydbio.2004.01.036. View

14.

Wu B, Dong F, Ma X, Wang X, Lin F, Liu H . Localization and expression of histone H2A variants during mouse oogenesis and preimplantation embryo development. Genet Mol Res. 2014; 13(3):5929-39. DOI: 10.4238/2014.August.7.8. View

15.

Kreidberg J, Sariola H, LORING J, Maeda M, Pelletier J, Housman D . WT-1 is required for early kidney development. Cell. 1993; 74(4):679-91. DOI: 10.1016/0092-8674(93)90515-r. View

16.

Bergeron L, Perez G, MacDonald G, Shi L, Sun Y, Jurisicova A . Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 1998; 12(9):1304-14. PMC: 316779. DOI: 10.1101/gad.12.9.1304. View

17.

Runyan C, Schaible K, Molyneaux K, Wang Z, Levin L, Wylie C . Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development. 2006; 133(24):4861-9. DOI: 10.1242/dev.02688. View

18.

Haywood M, Spaliviero J, Jimemez M, King N, Handelsman D, Allan C . Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology. 2003; 144(2):509-17. DOI: 10.1210/en.2002-220710. View

19.

Magnusdottir E, Dietmann S, Murakami K, Gunesdogan U, Tang F, Bao S . A tripartite transcription factor network regulates primordial germ cell specification in mice. Nat Cell Biol. 2013; 15(8):905-15. PMC: 3796875. DOI: 10.1038/ncb2798. View

20.

Kent J, Wheatley S, Andrews J, Sinclair A, Koopman P . A male-specific role for SOX9 in vertebrate sex determination. Development. 1996; 122(9):2813-22. DOI: 10.1242/dev.122.9.2813. View