Antibacterial Activity of Ro 17-2301 and Other Antimicrobial Agents Against Cefotaxime-resistant Aerobic Gram-negative Bacilli

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1986 Jan 1

PMID 3079583

Citations 3

Authors

C A Benson

F E WALTON

G M Trenholme

Affiliations

Soon will be listed here.

Abstract

The in vitro activity of Ro 17-2301 was determined and compared with those of aztreonam, ceftazidime, amikacin, and piperacillin against 141 cefotaxime-resistant gram-negative bacilli. Ro 17-2301 was bactericidal, and its activity against the majority of these organisms was equal or superior to those of ceftazidime, aztreonam, and piperacillin. An inoculum effect of Ro 17-2301 and aztreonam for many Pseudomonas aeruginosa and Enterobacter spp. isolates was demonstrated.

Citing Articles

In vitro susceptibility of Citrobacter species to various antimicrobial agents.

Samonis G, Ho D, Gooch G, Rolston K, Bodey G Antimicrob Agents Chemother. 1987; 31(5):829-30.

PMID: 3606084 PMC: 174846. DOI: 10.1128/AAC.31.5.829.

Comparative in vitro activity of A-56268 (TE-031) against gram-positive and gram-negative bacteria and Chlamydia trachomatis.

Benson C, Segreti J, Kessler H, Hines D, Goodman L, Kaplan R Eur J Clin Microbiol. 1987; 6(2):173-8.

PMID: 2954818 DOI: 10.1007/BF02018203.

Carumonam enhances reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5.

Overbeek B, Schellekens J, Lippe W, Dekker B, Verhoef J J Clin Microbiol. 1987; 25(6):1009-13.

PMID: 2439534 PMC: 269125. DOI: 10.1128/jcm.25.6.1009-1013.1987.

References

Sykes R, Bonner D, Bush K, Georgopapadakou N, Wells J . Monobactams--monocyclic beta-lactam antibiotics produced by bacteria. J Antimicrob Chemother. 1981; 8 Suppl E:1-16. DOI: 10.1093/jac/8.suppl_e.1. View

Phillips I, King A, Shannon K, Warren C . SQ 26,776: in-vitro antibacterial activity and susceptibility to beta-lactamases. J Antimicrob Chemother. 1981; 8 Suppl E:103-10. DOI: 10.1093/jac/8.suppl_e.103. View

Wise R, Andrews J, Hancox J . SQ 26,776, a novel beta-lactam: an in-vitro comparison with other antimicrobial agents. J Antimicrob Chemother. 1981; 8 Suppl E:39-47. DOI: 10.1093/jac/8.suppl_e.39. View

McNulty C, Garden G, Ashby J, Wise R . Pharmacokinetics and tissue penetration of carumonam, a new synthetic monobactam. Antimicrob Agents Chemother. 1985; 28(3):425-7. PMC: 180266. DOI: 10.1128/AAC.28.3.425. View

Eng R, Smith S, Cherubin C . Inoculum effect of new beta-lactam antibiotics on Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1984; 26(1):42-7. PMC: 179914. DOI: 10.1128/AAC.26.1.42. View