The Association Between Different Patterns of Traditional Chinese Medicine Treatment and All-Cause Mortality Among Cancer Patients

Overview

Journal Integr Cancer Ther

Publisher Sage Publications

Specialties Oncology
Pharmacology

Date 2019 Feb 23

PMID 30791738

Citations 8

Authors

Shao-Yi Lu

Jian-Jung Chen

Jiann-I Pan

Zi-Xuan Fu

Jung-Lun Wu

Tsung-Cheng Hsieh

Affiliations

Soon will be listed here.

Abstract

Background: Cancer patients receiving Western medical treatment, frequently seek Traditional Chinese Medicine (TCM) to alleviate adverse effects and prolong survival.

Objective: This study evaluated the association between the use of TCM and cancer survival rate. Research into the effect of TCM on patient survival is limited, this analysis focused on 3 patterns of TCM use.

Methods: Three retrospective cohorts with different patterns of TCM use were selected from the National Health Insurance Research Database of Taiwan and analyzed. Patients with newly diagnosed cancer between 1997 and 2012 were classified into groups of prediagnosis, postdiagnosis, and continuous TCM use associated with awareness of cancer diagnosis. All demographic and clinical data were analyzed.

Results: After propensity score matching, longevity of the postdiagnosis and continuous TCM user was significantly longer than the non-TCM user. The adjusted hazard ratios of death in postdiagnosis and continuous TCM use groups (0.59 and 0.61, respectively) were lower than the non-TCM use group.

Conclusion: The analysis suggests that cancer patients using TCM in conjunction with Western medical treatment exhibited a higher survival rate than patients not using TCM treatment.

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References

McCall M, Graham P, Bathe O . Quality of life: A critical outcome for all surgical treatments of gastric cancer. World J Gastroenterol. 2016; 22(3):1101-13. PMC: 4716023. DOI: 10.3748/wjg.v22.i3.1101. View

Lee Y, Chen T, Shih Y, Tsai C, Chang C, Liang H . Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: a population-based study. Cancer. 2014; 120(9):1338-44. DOI: 10.1002/cncr.28579. View

Hu B, Wang S, Du Q . Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside. World J Hepatol. 2015; 7(9):1209-32. PMC: 4438495. DOI: 10.4254/wjh.v7.i9.1209. View

Ye L, Jia Y, Ji K, Sanders A, Xue K, Ji J . Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis. Oncol Lett. 2015; 10(3):1240-1250. PMC: 4533180. DOI: 10.3892/ol.2015.3459. View

Yoshida Y, Wang M, Liu J, Shan B, Yamashita U . Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int J Immunopharmacol. 1997; 19(7):359-70. DOI: 10.1016/s0192-0561(97)00076-3. View

Danhier F, Feron O, Preat V . To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release. 2010; 148(2):135-46. DOI: 10.1016/j.jconrel.2010.08.027. View

Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M . How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther. 2011; 11(3):187-203. DOI: 10.1177/1534735411423920. View

Li X, Yang G, Li X, Zhang Y, Yang J, Chang J . Traditional Chinese medicine in cancer care: a review of controlled clinical studies published in chinese. PLoS One. 2013; 8(4):e60338. PMC: 3616129. DOI: 10.1371/journal.pone.0060338. View

Liao Y, Li C, Lin C, Lin J, Chiang J, Li T . Traditional Chinese medicine as adjunctive therapy improves the long-term survival of lung cancer patients. J Cancer Res Clin Oncol. 2017; 143(12):2425-2435. DOI: 10.1007/s00432-017-2491-6. View

10.

Lin H, Lin C, Huang W, Shangkuan W, Kang B, Chu Y . The use of adjunctive traditional Chinese medicine therapy and survival outcome in patients with head and neck cancer: a nationwide population-based cohort study. QJM. 2015; 108(12):959-65. DOI: 10.1093/qjmed/hcv079. View

11.

Garcia M, McQuade J, Haddad R, Patel S, Lee R, Yang P . Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol. 2013; 31(7):952-60. PMC: 3577953. DOI: 10.1200/JCO.2012.43.5818. View

12.

Liu J, Wang S, Zhang Y, Fan H, Lin H . Traditional Chinese medicine and cancer: History, present situation, and development. Thorac Cancer. 2015; 6(5):561-9. PMC: 4567000. DOI: 10.1111/1759-7714.12270. View

13.

Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H . Gastric cancer. Lancet. 2016; 388(10060):2654-2664. DOI: 10.1016/S0140-6736(16)30354-3. View

14.

Shen H, Wen S . Effect of early use of Chinese herbal products on mortality rate in patients with lung cancer. J Ethnopharmacol. 2017; 211:1-8. DOI: 10.1016/j.jep.2017.09.025. View

15.

Liu S, Cheng Y . Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapy. J Ethnopharmacol. 2012; 140(3):614-23. DOI: 10.1016/j.jep.2012.01.047. View

16.

Chen X, Deng L, Jiang X, Wu T . Chinese herbal medicine for oesophageal cancer. Cochrane Database Syst Rev. 2016; (1):CD004520. PMC: 10217096. DOI: 10.1002/14651858.CD004520.pub7. View

17.

Pu C, Lan V, Lan C, Lang H . The determinants of traditional Chinese medicine and acupuncture utilization for cancer patients with simultaneous conventional treatment. Eur J Cancer Care (Engl). 2008; 17(4):340-9. DOI: 10.1111/j.1365-2354.2007.00865.x. View

18.

Hofseth L, Wargovich M . Inflammation, cancer, and targets of ginseng. J Nutr. 2006; 137(1 Suppl):183S-185S. DOI: 10.1093/jn/137.1.183S. View

19.

Liao Y, Lin C, Lai H, Chiang J, Lin J, Li T . Adjunctive traditional Chinese medicine therapy improves survival of liver cancer patients. Liver Int. 2015; 35(12):2595-602. DOI: 10.1111/liv.12847. View

20.

Brustin R, Toledano M, Geffen T, Goona R, Hochberg M, Kreisberg B . Immune Modulation and Treatment of Human Papilloma Virus-Related Warts with Energetics of Living Systems Acupuncture. Med Acupunct. 2017; 29(3):145-154. PMC: 5512330. DOI: 10.1089/acu.2017.1225. View