Resveratrol Suppresses the Invasion and Migration of Human Gastric Cancer Cells Via Inhibition of MALAT1-mediated Epithelial-to-mesenchymal Transition

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2019 Feb 21

PMID 30783423

Citations 30

Authors

Zhuying Yang

Qigui Xie

Zhanlei Chen

Haibin Ni

Liang Xia

Qiufeng Zhao

Zhiyun Chen

Peifeng Chen

Affiliations

Soon will be listed here.

Abstract

Resveratrol, a natural polyphenolic phytoalexin, was reported to exert multiple anticancer effects as a traditional Chinese medicine. However, research regarding the anticancer mechanism of resveratrol for the treatment and prevention of gastric cancer has reported conflicting results. In the present study, it was determined that resveratrol inhibited cell viability in a dose-dependent manner in the human gastric cancer cell line BGC823. Cell migration and invasion were suppressed significantly following treatment with 200 µM resveratrol. Additionally, resveratrol inhibited metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression, which was overexpressed in gastric cancer cells. Further experiments revealed that MALAT1 knockdown suppressed cell viability, migration, invasion and epithelial-to-mesenchymal transition in BGC823 cells. The present study indicated that resveratrol inhibited migration and invasion in human gastric cancer cells via suppressing MALAT1-mediated epithelial-to-mesenchymal transition, providing novel evidence for understanding the anticancer mechanism of resveratrol.

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