Silver Nanoparticles: Synthesis and Application for Nanomedicine

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Feb 21

PMID 30781560

Citations 309

Authors

Sang Hun Lee

Bong-Hyun Jun

Affiliations

Soon will be listed here.

Abstract

Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver nanoparticles (AgNPs) have great potential in a broad range of applications as antimicrobial agents, biomedical device coatings, drug-delivery carriers, imaging probes, and diagnostic and optoelectronic platforms, since they have discrete physical and optical properties and biochemical functionality tailored by diverse size- and shape-controlled AgNPs. In this review, we aimed to present major routes of synthesis of AgNPs, including physical, chemical, and biological synthesis processes, along with discrete physiochemical characteristics of AgNPs. We also discuss the underlying intricate molecular mechanisms behind their plasmonic properties on mono/bimetallic structures, potential cellular/microbial cytotoxicity, and optoelectronic property. Lastly, we conclude this review with a summary of current applications of AgNPs in nanoscience and nanomedicine and discuss their future perspectives in these areas.

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References

Klaus T, Joerger R, Olsson E, Granqvist C . Silver-based crystalline nanoparticles, microbially fabricated. Proc Natl Acad Sci U S A. 1999; 96(24):13611-4. PMC: 24112. DOI: 10.1073/pnas.96.24.13611. View

Joerger R, Olsson E, Granqvist C . Bacteria as workers in the living factory: metal-accumulating bacteria and their potential for materials science. Trends Biotechnol. 2001; 19(1):15-20. DOI: 10.1016/s0167-7799(00)01514-6. View

Jin R, Cao Y, Mirkin C, Kelly K, Schatz G, Zheng J . Photoinduced conversion of silver nanospheres to nanoprisms. Science. 2001; 294(5548):1901-3. DOI: 10.1126/science.1066541. View

Haes A, Van Duyne R . A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. J Am Chem Soc. 2002; 124(35):10596-604. DOI: 10.1021/ja020393x. View

Sun Y, Xia Y . Shape-controlled synthesis of gold and silver nanoparticles. Science. 2002; 298(5601):2176-9. DOI: 10.1126/science.1077229. View

Lakowicz J, Malicka J, Gryczynski I . Silver particles enhance emission of fluorescent DNA oligomers. Biotechniques. 2003; 34(1):62-6, 68. PMC: 2729162. DOI: 10.2144/03341st01. View

Sondi I, Salopek-Sondi B . Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. 2004; 275(1):177-82. DOI: 10.1016/j.jcis.2004.02.012. View

Aslan K, Gryczynski I, Malicka J, Matveeva E, Lakowicz J, Geddes C . Metal-enhanced fluorescence: an emerging tool in biotechnology. Curr Opin Biotechnol. 2005; 16(1):55-62. PMC: 6853068. DOI: 10.1016/j.copbio.2005.01.001. View

Loo C, Lowery A, Halas N, West J, Drezek R . Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett. 2005; 5(4):709-11. DOI: 10.1021/nl050127s. View

10.

Sonnichsen C, Reinhard B, Liphardt J, Alivisatos A . A molecular ruler based on plasmon coupling of single gold and silver nanoparticles. Nat Biotechnol. 2005; 23(6):741-5. DOI: 10.1038/nbt1100. View

11.

Evanoff Jr D, Chumanov G . Synthesis and optical properties of silver nanoparticles and arrays. Chemphyschem. 2005; 6(7):1221-31. DOI: 10.1002/cphc.200500113. View

12.

Oliveira M, Ugarte D, Zanchet D, Zarbin A . Influence of synthetic parameters on the size, structure, and stability of dodecanethiol-stabilized silver nanoparticles. J Colloid Interface Sci. 2005; 292(2):429-35. DOI: 10.1016/j.jcis.2005.05.068. View

13.

Lee S, Morrill A, Moskovits M . Hot spots in silver nanowire bundles for surface-enhanced Raman spectroscopy. J Am Chem Soc. 2006; 128(7):2200-1. DOI: 10.1021/ja0578350. View

14.

Wiley B, Xiong Y, Li Z, Yin Y, Xia Y . Right bipyramids of silver: a new shape derived from single twinned seeds. Nano Lett. 2006; 6(4):765-8. DOI: 10.1021/nl060069q. View

15.

Lee K, El-Sayed M . Dependence of the enhanced optical scattering efficiency relative to that of absorption for gold metal nanorods on aspect ratio, size, end-cap shape, and medium refractive index. J Phys Chem B. 2006; 109(43):20331-8. DOI: 10.1021/jp054385p. View

16.

Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K . In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett. 2006; 6(10):2225-31. DOI: 10.1021/nl061517x. View

17.

Kumar S, Abyaneh M, Gosavi S, Kulkarni S, Pasricha R, Ahmad A . Nitrate reductase-mediated synthesis of silver nanoparticles from AgNO3. Biotechnol Lett. 2007; 29(3):439-45. DOI: 10.1007/s10529-006-9256-7. View

18.

Lengke M, Fleet M, Southam G . Biosynthesis of silver nanoparticles by filamentous cyanobacteria from a silver(I) nitrate complex. Langmuir. 2007; 23(5):2694-9. DOI: 10.1021/la0613124. View

19.

Wiley B, Chen Y, McLellan J, Xiong Y, Li Z, Ginger D . Synthesis and optical properties of silver nanobars and nanorice. Nano Lett. 2007; 7(4):1032-6. DOI: 10.1021/nl070214f. View

20.

TURKEVICH J, Kim G . Palladium: preparation and catalytic properties of particles of uniform size. Science. 1970; 169(3948):873-9. DOI: 10.1126/science.169.3948.873. View