The First Identification of Nesfatin-1-expressing Neurons in the Human Bed Nucleus of the Stria Terminalis

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2019 Feb 17

PMID 30770997

Citations 2

Authors

Artur Palasz

Katarzyna Bogus

Aleksandra Suszka-Switek

Andrzej Kaskosz

Shirley Saint-Remy

Aneta Piwowarczyk-Nowak

Lukasz Filipczyk

John J Worthington

Kinga Mordecka-Chamera

Karol Kostro

Grzegorz Bajor

Ryszard Wiaderkiewicz

Affiliations

Soon will be listed here.

Abstract

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Nesfatin-1-expressing neurons were identified for the first time in several regions of the BNST using both immunohistochemical and fluorescent methods. This may implicate a potential contribution of this neuropeptide to the BNST-related mechanisms of stress/reward responses in the human brain.

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