Current Understanding of the Role of Nesfatin-1

Overview

Journal J Endocr Soc

Specialty Endocrinology

Date 2018 Oct 11

PMID 30302423

Citations 37

Authors

Martha A Schalla

Andreas Stengel

Affiliations

Soon will be listed here.

Abstract

Nesfatin-1 was discovered in 2006 and implicated in the regulation of food intake. Subsequently, its widespread central and peripheral distribution gave rise to additional effects. Indeed, a multitude of actions were described, including modulation of gastrointestinal functions, glucose and lipid metabolism, thermogenesis, mediation of anxiety and depression, as well as cardiovascular and reproductive functions. Recent years have witnessed a great increase in our knowledge of these effects and their underlying mechanisms, which will be discussed in the present review. Lastly, gaps in knowledge will be highlighted to foster further studies.

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