Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands

Overview

Journal Inorg Chem

Specialty Chemistry

Date 2019 Feb 15

PMID 30763081

Citations 17

Authors

Christian Reichardt

Susan Monro

Fabian H Sobotta

Katsuya L Colon

Tariq Sainuddin

Mat Stephenson

Eric Sampson

John Roque 3rd

Huimin Yin

Johannes C Brendel

Colin G Cameron

Sherri McFarland

Benjamin Dietzek

Affiliations

Soon will be listed here.

Abstract

This study investigates the correlation between photocytotoxicity and the prolonged excited-state lifetimes exhibited by certain Ru(II) polypyridyl photosensitizers comprised of π-expansive ligands. The eight metal complexes selected for this study differ markedly in their triplet state configurations and lifetimes. Human melanoma SKMEL28 and human leukemia HL60 cells were used as in vitro models to test photocytotoxicity induced by the compounds when activated by either broadband visible or monochromatic red light. The photocytotoxicities of the metal complexes investigated varied over 2 orders of magnitude and were positively correlated with their excited-state lifetimes. The complexes with the longest excited-state lifetimes, contributed by low-lying IL states, were the most phototoxic toward cancer cells under all conditions.

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