Light-activated Ruthenium Complexes Photobind DNA and Are Cytotoxic in the Photodynamic Therapy Window

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2012 Aug 22

PMID 22908094

Citations 69

Authors

Erin Wachter

David K Heidary

Brock S Howerton

Sean Parkin

Edith C Glazer

Affiliations

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Abstract

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

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