The Frequency of Clones of Cytotoxic Lymphocytes Generated by H-2 Antigens

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1978 Jul 1

PMID 307590

Citations 1

Authors

J Marbrook

Y Nawa

J F Miller

Affiliations

Soon will be listed here.

Abstract

By using a culture system that allows the segregation of individual precursors of cytotoxic lymphocytes, the number of clones generated by cells from different combinations of congenic mice have been measured. It has been found that 0.3% of the total anti-H2d clones are generated by stimulators which differ predominantly at the H-2 locus. The contribution of non-H-2 antigens to anti-H-2 responses is discussed.

Citing Articles

The receptor specificity of alloreactive T cells. Distinction between stimulator K, I, and D region products and degeneracy of third-party H-2 recognition by low-affinity T cells.

Nagy Z, Elliott B J Exp Med. 1979; 150(6):1520-37.

PMID: 159939 PMC: 2185742. DOI: 10.1084/jem.150.6.1520.

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