Low Density of Thy 1 Antigen on Mouse Effector Cells Mediating Natural Cytotoxicity Against Tumor Cells

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1978 Jul 1

PMID 307576

Citations 45

Authors

R B Herberman

M E Nunn

H T HOLDEN

Affiliations

Soon will be listed here.

Abstract

Mouse effector cells mediating natural cell-mediated cytotoxicity against tumor cells were found to contain a low density of Thy 1 antigen. Treatment of nude spleen cells, or spleen cells from mice in which natural reactivity was boosted, with anti-Thy 1.2 plus complement resulted in a substantial decrease in cytotoxicity. The spontaneous cytotoxic reactivity of young, thymus-bearing mice was resistant to such treatment, but repeated exposure to anti-Thy 1.2 plus complement did cause a decrease in lytic activity. By use of congenic anti-Thy 1.2 and effector cells from mice congenic for Thy 1, the effects of the treatment were shown to be specific for Thy 1.2 antigen.

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