Mitochondrial Integrity in Neurodegeneration

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2019 Feb 13

PMID 30746905

Citations 34

Authors

Katrina Cowan

Oleg Anichtchik

Shouqing Luo

Affiliations

Soon will be listed here.

Abstract

The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial dysfunction is a key pathological process in several neurodegenerative diseases. Mitochondria are mostly important for energy production; however, they also have roles in Ca homeostasis, ROS production, and apoptosis. There are two major systems in place, which regulate mitochondrial integrity, mitochondrial dynamics, and mitophagy. These two processes remove damaged mitochondria from cells and protect the functional mitochondrial population. These quality control systems often become dysfunctional during neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, causing mitochondrial dysfunction and severe neurological symptoms.

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