Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis

Overview

Journal Annu Rev Physiol

Publisher Annual Reviews

Specialty Physiology

Date 2019 Feb 12

PMID 30742781

Citations 27

Authors

Massimiliano Mazzone

Gabriele Bergers

Affiliations

Soon will be listed here.

Abstract

Research over the last decades has provided strong evidence for the pivotal role of the tumor-associated blood and lymphatic vasculature in supporting immunoevasion and in subverting T cell-mediated immunosurveillance. Conversely, tumor blood and lymphatic vessel growth is in part regulated by the immune system, with infiltrating innate as well as adaptive immune cells providing both immunosuppressive and various angiogenic signals. Thus, tumor angiogenesis and escape of immunosurveillance are two cancer hallmarks that are tightly linked and interregulated by cell constituents from compartments secreting both chemokines and cytokines. In this review, we discuss the implication and regulation of innate and adaptive immune cells in regulating blood and lymphatic angiogenesis in tumor progression and metastases. Moreover, we also highlight novel therapeutic approaches that target the tumor vasculature as well as the immune compartment to sustain and improve therapeutic efficacy in cancer.

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