Environmental Exposures and Mechanisms in Allergy and Asthma Development

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2019 Feb 12

PMID 30741719

Citations 118

Authors

Liza Bronner Murrison

Eric B Brandt

Jocelyn Biagini Myers

Gurjit K Khurana Hershey

Affiliations

Soon will be listed here.

Abstract

Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Research shows an association between the rise of allergic diseases and increasingly modern Westernized lifestyles, which are characterized by increased urbanization, time spent indoors, and antibiotic usage. These environmental changes result in increased exposure to air and traffic pollution, fungi, infectious agents, tobacco smoke, and other early-life and lifelong risk factors for the development and exacerbation of asthma and allergic diseases. It is increasingly recognized that the timing, load, and route of allergen exposure affect allergic disease phenotypes and development. Still, our ability to prevent allergic diseases is hindered by gaps in understanding of the underlying mechanisms and interaction of environmental, viral, and allergen exposures with immune pathways that impact disease development. This Review highlights epidemiologic and mechanistic evidence linking environmental exposures to the development and exacerbation of allergic airway responses.

Citing Articles

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