Effects of Different Comorbidities on Health-Related Quality of Life Among Respiratory Patients in Vietnam

Overview

Journal J Clin Med

Specialty General Medicine

Date 2019 Feb 10

PMID 30736474

Citations 21

Authors

Chau Quy Ngo

Phuong Thu Phan

Giap Van Vu

Quyen Le Thi Pham

Long Hoang Nguyen

Giang Thu Vu

Tung Thanh Tran

Huong Lan Thi Nguyen

Bach Xuan Tran

Carl A Latkin

Cyrus S H Ho

Roger C M Ho

Affiliations

Soon will be listed here.

Abstract

Comorbidities are common in respiratory disease patients and have been well-known to impact their quality of life. The objective of this study is to estimate the minimal clinically important difference (MCID) of the health-related quality of life (HRQOL) among respiratory disease patients with different comorbidities in a Vietnamese tertiary hospital. We performed a cross-sectional study from October to November 2016 at the Respiratory Center of Bach Mai Hospital, Hanoi, with a total of 508 participants. Information about socio-economic characteristics, HRQOL and comorbidities of participants was collected. ANOVA was used to identify MCID between patients with and without specific comorbid conditions. Tobit regression was used to explore the associations between comorbidities and the HRQOL. Results showed that the prevalence of cardiovascular comorbidities was 23.8%, followed by musculoskeletal diseases (12.0%), digestive diseases (11.8%), endocrine diseases (10.0%), kidney diseases (5.1%) and ear, nose, and throat diseases (4.5%). Regarding HRQOL, having a problem in pain/discomfort was observed in 61.0% of participants, followed by anxiety/depression (48.2%). Mean EQ-5D index was 0.66 (SD (Standard Deviation) = 0.31). The significant MCID ( < 0.05) was found between patients with and without cardiovascular diseases, musculoskeletal diseases, kidney diseases, and endocrine diseases. The multivariate regression model showed that only musculoskeletal diseases were found to be related with the marked decrement of EQ-5D index score (Coef. = -0.13; 95% CI (Confident Interval) = -0.23; -0.02). Suffering at least one chronic illness was correlated to the marked decrease of EQ-5D index score (Coef. = -0.09; 95%CI = -0.17; -0.01). These results underline the importance of appropriate pain management as well as the provision of an interprofessional care approach to patients in order to alleviate the burden of comorbidities to their treatment outcomes and HRQOL.

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References

Hays R, Woolley J . The concept of clinically meaningful difference in health-related quality-of-life research. How meaningful is it?. Pharmacoeconomics. 2001; 18(5):419-23. DOI: 10.2165/00019053-200018050-00001. View

Wijnhoven H, Kriegsman D, Hesselink A, de Haan M, Schellevis F . The influence of co-morbidity on health-related quality of life in asthma and COPD patients. Respir Med. 2003; 97(5):468-75. DOI: 10.1053/rmed.2002.1463. View

Eton D, Cella D, Yost K, Yount S, Peterman A, Neuberg D . A combination of distribution- and anchor-based approaches determined minimally important differences (MIDs) for four endpoints in a breast cancer scale. J Clin Epidemiol. 2004; 57(9):898-910. DOI: 10.1016/j.jclinepi.2004.01.012. View

Katsura H, Yamada K, Kida K . Both generic and disease specific health-related quality of life are deteriorated in patients with underweight COPD. Respir Med. 2005; 99(5):624-30. DOI: 10.1016/j.rmed.2004.09.017. View

Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois M . Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res. 2006; 15(1):83-91. DOI: 10.1007/s11136-005-8661-z. View

Swallow E, Reyes D, Hopkinson N, Man W, Porcher R, Cetti E . Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax. 2006; 62(2):115-20. PMC: 2111256. DOI: 10.1136/thx.2006.062026. View

Charlson M, Charlson R, Briggs W, Hollenberg J . Can disease management target patients most likely to generate high costs? The impact of comorbidity. J Gen Intern Med. 2007; 22(4):464-9. PMC: 1829434. DOI: 10.1007/s11606-007-0130-7. View

Rabe K, Hurd S, Anzueto A, Barnes P, Buist S, Calverley P . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007; 176(6):532-55. DOI: 10.1164/rccm.200703-456SO. View

Cazzola M, MacNee W, Martinez F, Rabe K, Franciosi L, Barnes P . Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J. 2008; 31(2):416-69. DOI: 10.1183/09031936.00099306. View

10.

Seymour J, Spruit M, Hopkinson N, Natanek S, Man W, Jackson A . The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J. 2009; 36(1):81-8. PMC: 3039205. DOI: 10.1183/09031936.00104909. View

11.

Sundh J, Stallberg B, Lisspers K, Montgomery S, Janson C . Co-morbidity, body mass index and quality of life in COPD using the Clinical COPD Questionnaire. COPD. 2011; 8(3):173-81. DOI: 10.3109/15412555.2011.560130. View

12.

Patel A, Hurst J . Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art. Expert Rev Respir Med. 2011; 5(5):647-62. DOI: 10.1586/ers.11.62. View

13.

Agborsangaya C, Lau D, Lahtinen M, Cooke T, Johnson J . Health-related quality of life and healthcare utilization in multimorbidity: results of a cross-sectional survey. Qual Life Res. 2012; 22(4):791-9. DOI: 10.1007/s11136-012-0214-7. View

14.

Burgel P, Escamilla R, Perez T, Carre P, Caillaud D, Chanez P . Impact of comorbidities on COPD-specific health-related quality of life. Respir Med. 2012; 107(2):233-41. DOI: 10.1016/j.rmed.2012.10.002. View

15.

Almagro P, Cabrera F, Diez J, Boixeda R, Alonso Ortiz M, Murio C . Comorbidities and short-term prognosis in patients hospitalized for acute exacerbation of COPD: the EPOC en Servicios de medicina interna (ESMI) study. Chest. 2013; 142(5):1126-1133. DOI: 10.1378/chest.11-2413. View

16.

Janson C, Marks G, Buist S, Gnatiuc L, Gislason T, McBurnie M . The impact of COPD on health status: findings from the BOLD study. Eur Respir J. 2013; 42(6):1472-83. PMC: 3844139. DOI: 10.1183/09031936.00153712. View

17.

Koskela J, Kilpelainen M, Kupiainen H, Mazur W, Sintonen H, Boezen M . Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD. BMC Pulm Med. 2014; 14:102. PMC: 4229911. DOI: 10.1186/1471-2466-14-102. View

18.

Shiroiwa T, Fukuda T, Ikeda S, Igarashi A, Noto S, Saito S . Japanese population norms for preference-based measures: EQ-5D-3L, EQ-5D-5L, and SF-6D. Qual Life Res. 2015; 25(3):707-19. PMC: 4759213. DOI: 10.1007/s11136-015-1108-2. View

19.

Chen P, Lin K, Liing R, Wu C, Chen C, Chang K . Validity, responsiveness, and minimal clinically important difference of EQ-5D-5L in stroke patients undergoing rehabilitation. Qual Life Res. 2015; 25(6):1585-96. DOI: 10.1007/s11136-015-1196-z. View

20.

Su X, Ren Y, Li M, Zhao X, Kong L, Kang J . Prevalence of Comorbidities in Asthma and Nonasthma Patients: A Meta-analysis. Medicine (Baltimore). 2016; 95(22):e3459. PMC: 4900697. DOI: 10.1097/MD.0000000000003459. View