Eavesdropping on the Conversation Between Immune Cells and the Skin Epithelium

Overview

Journal Int Immunol

Specialty Allergy & Immunology

Date 2019 Feb 6

PMID 30721971

Citations 4

Authors

Shoiab Bukhari

Aaron F Mertz

Shruti Naik

Affiliations

Soon will be listed here.

Abstract

The skin epithelium covers our body and serves as a vital interface with the external environment. Here, we review the context-specific interactions between immune cells and the epithelium that underlie barrier fitness and function. We highlight the mechanisms by which these two systems engage each other and how immune-epithelial interactions are tuned by microbial and inflammatory stimuli. Epithelial homeostasis relies on a delicate balance of immune surveillance and tolerance, breakdown of which results in disease. In addition to their canonical immune functions, resident and recruited immune cells also supply the epithelium with instructive signals to promote repair. Decoding the dialogue between immunity and the epithelium therefore has great potential for boosting barrier function or mitigating inflammatory epithelial diseases.

Citing Articles

Interleukin-17 governs hypoxic adaptation of injured epithelium.

Konieczny P, Xing Y, Sidhu I, Subudhi I, Mansfield K, Hsieh B Science. 2022; 377(6602):eabg9302.

PMID: 35709248 PMC: 9753231. DOI: 10.1126/science.abg9302.

Epithelial-immune crosstalk in health and disease.

Rosenblum D, Naik S Curr Opin Genet Dev. 2022; 74:101910.

PMID: 35461159 PMC: 9170062. DOI: 10.1016/j.gde.2022.101910.

One Size Does Not Fit All: Diversifying Immune Function in the Skin.

Naik S J Immunol. 2022; 208(2):227-234.

PMID: 35017212 PMC: 8820520. DOI: 10.4049/jimmunol.2100758.

Loricrin: Past, Present, and Future.

Ishitsuka Y, Roop D Int J Mol Sci. 2020; 21(7).

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