Sentinel Node Navigation Surgery in Esophageal Cancer

Overview

Journal Ann Gastroenterol Surg

Date 2019 Jan 31

PMID 30697605

Citations 12

Authors

Hiroya Takeuchi

Yuko Kitagawa

Affiliations

Soon will be listed here.

Abstract

Over the last 20 years, the sentinel node (SN) concept has been widely applied to the surgical staging of both breast cancer and melanoma. However, the validity of this concept has been controversial for esophageal cancer, because SN mapping for esophageal cancer is not considered to be technically easy because of the complicated multidirectional lymphatic networks of the esophagus and mediastinum. Nevertheless, studies including meta-analyses indicated that SN mapping may be feasible in early esophageal cancer. Transthoracic esophagectomy with three-field lymphadenectomy was developed as a potential curative procedure for thoracic esophageal cancer. However, this highly invasive procedure might increase morbidity and reduce patients' quality of life (QOL) after esophagectomy. Although further validation based on multicenter trials using the standard protocol of SN mapping for esophageal cancer is required, SN navigation surgery would enable us to carry out personalized and limited lymph node dissection which might reduce morbidity and maintain patients' QOL.

Citing Articles

The different routes of lymph node metastases in esophageal cancer and its significance.

Hutchings H, Okereke I J Thorac Dis. 2023; 15(11):5873-5876.

PMID: 38090311 PMC: 10713315. DOI: 10.21037/jtd-23-1373.

History and evidence for state of the art of lymphadenectomy in esophageal cancer surgery.

Schuring N, van Berge Henegouwen M, Gisbertz S Dis Esophagus. 2023; 37(4).

PMID: 38048446 PMC: 10987971. DOI: 10.1093/dote/doad065.

Feasibility and Safety of Tailored Lymphadenectomy Using Sentinel Node-Navigated Surgery in Patients with High-Risk T1 Esophageal Adenocarcinoma.

Frederiks C, Overwater A, Bergman J, Pouw R, de Keizer B, Bennink R Ann Surg Oncol. 2023; 30(7):4002-4011.

PMID: 36959491 PMC: 10035969. DOI: 10.1245/s10434-023-13317-6.

Prognostic relevance of tumor-resident memory T cells in metastatic lymph nodes of esophageal squamous cell carcinoma.

Natsuki S, Tanaka H, Nishiyama M, Mori T, Deguchi S, Miki Y Cancer Sci. 2023; 114(5):1846-1858.

PMID: 36748311 PMC: 10154829. DOI: 10.1111/cas.15750.

Current status and challenges in sentinel node navigation surgery for early gastric cancer.

Matsuda S, Irino T, Kawakubo H, Takeuchi H, Kitagawa Y Chin J Cancer Res. 2021; 33(2):150-158.

PMID: 34158735 PMC: 8181877. DOI: 10.21147/j.issn.1000-9604.2021.02.03.

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