Antiviral Activity of Itraconazole Against Type I Feline Coronavirus Infection

Overview

Journal Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2019 Jan 20

PMID 30658691

Citations 27

Authors

Tomomi Takano

Misuzu Akiyama

Tomoyoshi Doki

Tsutomu Hohdatsu

Affiliations

Soon will be listed here.

Abstract

Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.

Citing Articles

In Vitro Evaluation of Aryl Hydrocarbon Receptor Involvement in Feline Coronavirus Infection.

Del Sorbo L, Giugliano R, Cerracchio C, Iovane V, Salvatore M, Serra F Viruses. 2025; 17(2).

PMID: 40006982 PMC: 11860311. DOI: 10.3390/v17020227.

Feline infectious peritonitis: A comprehensive evaluation of clinical manifestations, laboratory diagnosis, and therapeutic approaches.

Moyadee W, Sunpongsri S, Choowongkomon K, Roytrakul S, Rattanasrisomporn A, Tansakul N J Adv Vet Anim Res. 2024; 11(1):19-26.

PMID: 38680809 PMC: 11055576. DOI: 10.5455/javar.2024.k742.

Lipid compartments and lipid metabolism as therapeutic targets against coronavirus.

Cesar-Silva D, Pereira-Dutra F, Giannini A, Maya-Monteiro C, de Almeida C Front Immunol. 2023; 14:1268854.

PMID: 38106410 PMC: 10722172. DOI: 10.3389/fimmu.2023.1268854.

Feline Infectious Peritonitis: European Advisory Board on Cat Diseases Guidelines.

Tasker S, Addie D, Egberink H, Hofmann-Lehmann R, Hosie M, Truyen U Viruses. 2023; 15(9).

PMID: 37766254 PMC: 10535984. DOI: 10.3390/v15091847.

Rottlerin-Liposome Inhibits the Endocytosis of Feline Coronavirus Infection.

Choi J, Jung S, Choi I, Kang Y, Lee D, Lee S Vet Sci. 2023; 10(6).

PMID: 37368766 PMC: 10302841. DOI: 10.3390/vetsci10060380.

References

McKinsey D, Wheat L, Cloud G, Pierce M, Black J, Bamberger D . Itraconazole prophylaxis for fungal infections in patients with advanced human immunodeficiency virus infection: randomized, placebo-controlled, double-blind study. National Institute of Allergy and Infectious Diseases Mycoses Study Group. Clin Infect Dis. 1999; 28(5):1049-56. DOI: 10.1086/514744. View

Hohdatsu T, Okada S, Ishizuka Y, Yamada H, Koyama H . The prevalence of types I and II feline coronavirus infections in cats. J Vet Med Sci. 1992; 54(3):557-62. DOI: 10.1292/jvms.54.557. View

Addie D, Schaap I, Nicolson L, Jarrett O . Persistence and transmission of natural type I feline coronavirus infection. J Gen Virol. 2003; 84(Pt 10):2735-2744. DOI: 10.1099/vir.0.19129-0. View

Kummrow M, Meli M, Haessig M, Goenczi E, Poland A, Pedersen N . Feline coronavirus serotypes 1 and 2: seroprevalence and association with disease in Switzerland. Clin Diagn Lab Immunol. 2005; 12(10):1209-15. PMC: 1247821. DOI: 10.1128/CDLI.12.10.1209-1215.2005. View

Hohdatsu T, Sasamoto T, Okada S, Koyama H . Antigenic analysis of feline coronaviruses with monoclonal antibodies (MAbs): preparation of MAbs which discriminate between FIPV strain 79-1146 and FECV strain 79-1683. Vet Microbiol. 1991; 28(1):13-24. PMC: 7117509. DOI: 10.1016/0378-1135(91)90096-x. View

Takano T, Katoh Y, Doki T, Hohdatsu T . Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo. Antiviral Res. 2013; 99(2):100-7. PMC: 7114111. DOI: 10.1016/j.antiviral.2013.04.016. View

Pedersen N . An update on feline infectious peritonitis: diagnostics and therapeutics. Vet J. 2014; 201(2):133-41. PMC: 7110619. DOI: 10.1016/j.tvjl.2014.04.016. View

Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K . Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking. Autophagy. 2014; 10(7):1241-55. PMC: 4203550. DOI: 10.4161/auto.28912. View

Neuman B, Angelini M, Buchmeier M . Does form meet function in the coronavirus replicative organelle?. Trends Microbiol. 2014; 22(11):642-7. PMC: 7127430. DOI: 10.1016/j.tim.2014.06.003. View

10.

Wang Y, Chueh L, Wan C . An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections. BMC Vet Res. 2014; 10:186. PMC: 4236817. DOI: 10.1186/s12917-014-0186-7. View

11.

Strating J, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L . Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep. 2015; 10(4):600-15. PMC: 4383725. DOI: 10.1016/j.celrep.2014.12.054. View

12.

Takano T, Nakano K, Doki T, Hohdatsu T . Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II. Arch Virol. 2015; 160(5):1163-70. PMC: 7086594. DOI: 10.1007/s00705-015-2370-x. View

13.

Takano T, Hohdatsu T . Serological diagnosis of feline coronavirus infection by immunochromatographic test. Methods Mol Biol. 2015; 1282:33-9. PMC: 7122596. DOI: 10.1007/978-1-4939-2438-7_3. View

14.

Takano T, Satomi Y, Oyama Y, Doki T, Hohdatsu T . Differential effect of cholesterol on type I and II feline coronavirus infection. Arch Virol. 2015; 161(1):125-33. PMC: 7086697. DOI: 10.1007/s00705-015-2655-0. View

15.

Kim Y, Liu H, Galasiti Kankanamalage A, Weerasekara S, Hua D, Groutas W . Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016; 12(3):e1005531. PMC: 4814111. DOI: 10.1371/journal.ppat.1005531. View

16.

Tekes G, Thiel H . Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis. Adv Virus Res. 2016; 96:193-218. PMC: 7112361. DOI: 10.1016/bs.aivir.2016.08.002. View

17.

Trinh M, Lu F, Li X, Das A, Liang Q, De Brabander J . Triazoles inhibit cholesterol export from lysosomes by binding to NPC1. Proc Natl Acad Sci U S A. 2016; 114(1):89-94. PMC: 5224357. DOI: 10.1073/pnas.1619571114. View

18.

Saag M, Dismukes W . Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother. 1988; 32(1):1-8. PMC: 172087. DOI: 10.1128/AAC.32.1.1. View

19.

Takano T, Endoh M, Fukatsu H, Sakurada H, Doki T, Hohdatsu T . The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection. Antiviral Res. 2017; 145:96-102. PMC: 7113792. DOI: 10.1016/j.antiviral.2017.07.022. View

20.

Jaimes J, Whittaker G . Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function. Virology. 2018; 517:108-121. PMC: 7112122. DOI: 10.1016/j.virol.2017.12.027. View