A Patient with Solid Gynecologic Cancer Causing Lactic Acidosis, Severe Hypercalcemia, and Hypoglycemia

Overview

Journal Clin Case Rep

Date 2019 Jan 19

PMID 30656010

Citations 5

Authors

John Hausken

Ellen M Haave

Hakon Haugaa

Else M Loberg

Ulf E Kongsgaard

Affiliations

Soon will be listed here.

Abstract

Though rare in cervical cancer patients, paraneoplastic syndrome usually presents with several endocrine and hormonal symptoms. Knowledge of the pathophysiology that underlies these abnormalities is beneficial to diagnosis and treatment. An interdisciplinary approach and test analysis prior to initiating specific treatment is recommended, though prognosis appears poor in advanced cases.

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A patient with solid gynecologic cancer causing lactic acidosis, severe hypercalcemia, and hypoglycemia.

Hausken J, Haave E, Haugaa H, Loberg E, Kongsgaard U Clin Case Rep. 2019; 7(1):64-70.

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References

BAXTER R, Holman S, Corbould A, Stranks S, Ho P, Braund W . Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab. 1995; 80(9):2700-8. DOI: 10.1210/jcem.80.9.7545698. View

Stewart A . Clinical practice. Hypercalcemia associated with cancer. N Engl J Med. 2005; 352(4):373-9. DOI: 10.1056/NEJMcp042806. View

Sillos E, Shenep J, Burghen G, Pui C, Behm F, Sandlund J . Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature. Cancer. 2001; 92(9):2237-46. DOI: 10.1002/1097-0142(20011101)92:9<2237::aid-cncr1569>3.0.co;2-9. View

Ruiz J, Singh A, Hart P . Type B lactic acidosis secondary to malignancy: case report, review of published cases, insights into pathogenesis, and prospects for therapy. ScientificWorldJournal. 2011; 11:1316-24. PMC: 5720012. DOI: 10.1100/tsw.2011.125. View

Frystyk J, Skjaerbaek C, Zapf J, Orskov H . Increased levels of circulating free insulin-like growth factors in patients with non-islet cell tumour hypoglycaemia. Diabetologia. 1998; 41(5):589-94. DOI: 10.1007/s001250050951. View

Viau M, Renaud M, Gregoire J, Sebastianelli A, Plante M . Paraneoplastic syndromes associated with gynecological cancers: A systematic review. Gynecol Oncol. 2017; 146(3):661-671. DOI: 10.1016/j.ygyno.2017.06.025. View

BAXTER R . The insulin-like growth factors and their binding proteins. Comp Biochem Physiol B. 1988; 91(2):229-35. DOI: 10.1016/0305-0491(88)90137-x. View

Vander Heiden M, Cantley L, Thompson C . Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009; 324(5930):1029-33. PMC: 2849637. DOI: 10.1126/science.1160809. View

Wu X, Tortolero-Luna G, Zhao H, Phatak D, Spitz M, Follen M . Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix. Clin Cancer Res. 2003; 9(9):3356-61. View

10.

Pelosof L, Gerber D . Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010; 85(9):838-54. PMC: 2931619. DOI: 10.4065/mcp.2010.0099. View

11.

Scott K . Non-islet cell tumor hypoglycemia. J Pain Symptom Manage. 2009; 37(4):e1-3. DOI: 10.1016/j.jpainsymman.2008.11.004. View

12.

Paraschiv B, Diaconu C, Toma C, Bogdan M . Paraneoplastic syndromes: the way to an early diagnosis of lung cancer. Pneumologia. 2015; 64(2):14-9. View

13.

Iglesias P, Diez J . Management of endocrine disease: a clinical update on tumor-induced hypoglycemia. Eur J Endocrinol. 2014; 170(4):R147-57. DOI: 10.1530/EJE-13-1012. View

14.

Teale J, Wark G . The effectiveness of different treatment options for non-islet cell tumour hypoglycaemia. Clin Endocrinol (Oxf). 2004; 60(4):457-60. DOI: 10.1111/j.1365-2265.2004.01989.x. View

15.

Lee S, Lee S, Lee S, Ju W, Kim S . Plasma levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with cervical neoplasia. J Gynecol Oncol. 2010; 21(3):174-80. PMC: 2948225. DOI: 10.3802/jgo.2010.21.3.174. View

16.

Thomas J, Kumar S . Nonislet cell tumor hypoglycemia. Case Rep Endocrinol. 2013; 2013:308086. PMC: 3806343. DOI: 10.1155/2013/308086. View

17.

Samani A, Yakar S, LeRoith D, Brodt P . The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev. 2006; 28(1):20-47. DOI: 10.1210/er.2006-0001. View

18.

Lumachi F, Brunello A, Roma A, Basso U . Medical treatment of malignancy-associated hypercalcemia. Curr Med Chem. 2008; 15(4):415-21. DOI: 10.2174/092986708783497346. View

19.

DeLellis R, Xia L . Paraneoplastic endocrine syndromes: a review. Endocr Pathol. 2004; 14(4):303-17. DOI: 10.1385/ep:14:4:303. View

20.

Durzynska J . IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (review). Oncol Rep. 2014; 32(6):2295-306. PMC: 4240475. DOI: 10.3892/or.2014.3505. View