Preclinical Models of Radiation-induced Lung Damage: Challenges and Opportunities for Small Animal Radiotherapy

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2019 Jan 18

PMID 30653332

Citations 15

Authors

Mihaela Ghita

Victoria Dunne

Gerard G Hanna

Kevin M Prise

Jaqueline P Williams

Karl T Butterworth

Affiliations

Soon will be listed here.

Abstract

Despite a major paradigm shift in radiotherapy planning and delivery over the past three decades with continuing refinements, radiation-induced lung damage (RILD) remains a major dose limiting toxicity in patients receiving thoracic irradiations. Our current understanding of the biological processes involved in RILD which includes DNA damage, inflammation, senescence and fibrosis, is based on clinical observations and experimental studies in mouse models using conventional radiation exposures. Whilst these studies have provided vital information on the pulmonary radiation response, the current implementation of small animal irradiators is enabling refinements in the precision and accuracy of dose delivery to mice which can be applied to studies of RILD. This review presents the current landscape of preclinical studies in RILD using small animal irradiators and highlights the challenges and opportunities for the further development of this emerging technology in the study of normal tissue damage in the lung.

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