A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury

Overview

Journal Radiat Res

Specialties Genetics
Radiology

Date 2021 Aug 3

PMID 34342637

Citations 9

Authors

David R Cassatt

Alex Gorovets

Banu Karimi-Shah

Rosemary Roberts

Paul W Price

Merriline M Satyamitra

Nushin Todd

Sue-Jane Wang

Libero Marzella

Affiliations

Soon will be listed here.

Abstract

Research and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Institute of Allergy and Infectious Diseases (NIAID) brought together medical, scientific and regulatory communities, including academic and industry subject matter experts, and government stakeholders from the Food and Drug Administration (FDA) and the Biomedical Advanced Research and Development Authority (BARDA), to identify critical research gaps, discuss current clinical practices for various forms of pulmonary damage, and consider available animal models for radiation-induced lung injury.

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