The Emerging Role of WISP Proteins in Tumorigenesis and Cancer Therapy

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2019 Jan 18

PMID 30651114

Citations 16

Authors

Yi Liu

Yizuo Song

Miaomiao Ye

Xiaoli Hu

Z Peter Wang

Xueqiong Zhu

Affiliations

Soon will be listed here.

Abstract

Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Because the understanding of a direct function of WISP proteins in cancer development and progression has begun to emerge, in this review article, we describe the physiological function of WISP proteins in a variety of human cancers. Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. Furthermore, we discuss that targeting WISP proteins could be a promising strategy for the treatment of human cancers. Hence, the regulation of WISP proteins could improve treatments for cancer patients.

Citing Articles

The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway.

Kim S, Yang K, Kim K, Kim H, Kim D, Chae J Cell Commun Signal. 2025; 23(1):98.

PMID: 39966869 PMC: 11837402. DOI: 10.1186/s12964-025-02094-2.

Identification and validation of CCN family genes to predict the prognosis in gastric cancer.

Chen H, Zhang X, Zhang Z, Li G, Li X, Yang S Discov Oncol. 2024; 15(1):610.

PMID: 39485579 PMC: 11530581. DOI: 10.1007/s12672-024-01459-2.

WISP1 and Macrophage Migration Inhibitory Factor in Respiratory Inflammation: Novel Insights and Therapeutic Potentials for Asthma and COPD.

Christopoulou M, Aletras A, Papakonstantinou E, Stolz D, Skandalis S Int J Mol Sci. 2024; 25(18).

PMID: 39337534 PMC: 11432718. DOI: 10.3390/ijms251810049.

Identification of New Chemoresistance-Associated Genes in Triple-Negative Breast Cancer by Single-Cell Transcriptomic Analysis.

Foutadakis S, Kordias D, Vatsellas G, Magklara A Int J Mol Sci. 2024; 25(13).

PMID: 38999963 PMC: 11241600. DOI: 10.3390/ijms25136853.

An overview of CCN4 (WISP1) role in human diseases.

Singh K, Oladipupo S J Transl Med. 2024; 22(1):601.

PMID: 38937782 PMC: 11212430. DOI: 10.1186/s12967-024-05364-8.

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