Molybdenum Sulfide-reduced Graphene Oxide P-n Heterojunction Nanosheets with Anchored Oxygen Generating Manganese Dioxide Nanoparticles for Enhanced Photodynamic Therapy

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Jan 17

PMID 30647890

Citations 12

Authors

Sutanu Kapri

Sayan Bhattacharyya

Affiliations

Soon will be listed here.

Abstract

In an unprecedented approach, p-n heterojunction nanosheets comprising ∼5 nm thick p-type MoS nanoplates integrated onto n-type nitrogen doped reduced graphene oxide (n-rGO) have been employed for photodynamic therapy (PDT). When near infrared (NIR) light with 980 nm wavelength was irradiated on this nanocomposite, effective electron-hole separation was obtained across the heterojunction. The nanosheets were modified with lipoic acid functionalized poly(ethylene glycol) to provide better biocompatibility and colloidal stability in physiological solution. The surface decorated 3-5 nm MnO nanoparticles (NPs) triggered the disproportionation of intracellular HO which improved generation of reactive oxygen species (ROS) for enhanced PDT cancer therapy, studied . The role of N-doping in rGO and the effect of immobilization of MnO NPs were systematically investigated by control experiments. Our smartly designed p-MoS/n-rGO-MnO-PEG nanosheets outperform conventional PDT agents by overcoming limitations such as low absorption band, unfavourable bioavailability and limitations in tissue oxygenation.

Citing Articles

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