Clinical Features and Determinants of Chronicity in Hepatitis E Virus Infection

Overview

Journal J Viral Hepat

Specialty Gastroenterology

Date 2019 Jan 13

PMID 30636092

Citations 18

Authors

Shivakumar Narayanan

Ameer Abutaleb

Kenneth E Sherman

Shyam Kottilil

Affiliations

Soon will be listed here.

Abstract

Hepatitis E virus (HEV) has traditionally been associated with an acute, self-limiting hepatitis and is not known to have any chronic sequelae. HEV genotypes 1 and 2, which are human pathogens, have been associated with this self-limiting presentation, in both sporadic and epidemic settings. HEV genotype 3, which is zoonotically transmitted, is increasingly being reported as a cause of chronic infection in immunocompromised patients. These include patients with solid organ transplants, patients receiving chemotherapy for haematologic malignancies and patients infected with HIV. Chronic infection is associated with rapidly progressing liver disease and extrahepatic manifestations including neurologic disorders. We review the clinical manifestations of chronic HEV infection and discuss factors determining persistence and chronicity of HEV.

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