Hepatitis E Virus and Neurologic Disorders

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2011 Feb 5

PMID 21291585

Citations 104

Authors

Nassim Kamar

Richard P Bendall

Jean Marie Peron

Pascal Cintas

Laurent Prudhomme

Jean Michel Mansuy

Lionel Rostaing

Frances Keane

Samreen Ijaz

Jacques Izopet

Harry R Dalton

Affiliations

Soon will be listed here.

Abstract

Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%): inflammatory polyradiculopathy (n = 3), Guillain-Barre syndrome (n = 1), bilateral brachial neuritis (n = 1), encephalitis (n = 1), and ataxia/proximal myopathy (n = 1). Three cases occurred in nonimmunocompromised patients with acute HEV infection, and 4 were in immunocompromised patients with chronic HEV infection. HEV RNA was detected in cerebrospinal fluid of all 4 patients with chronic HEV infection but not in that of 2 patients with acute HEV infection. Neurologic outcomes were complete resolution (n = 3), improvement with residual neurologic deficit (n = 3), and no improvement (n = 1). Neurologic disorders are an emerging extrahepatic manifestation of HEV infection.

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