Catalytic One-Step Deoxytrifluoromethylation of Alcohols

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2019 Jan 12

PMID 30632749

Citations 3

Authors

Francisco de Azambuja

Sydney M Lovrien

Patrick Ross

Brett R Ambler

Ryan A Altman

Affiliations

Soon will be listed here.

Abstract

A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access to target biologically active molecules, and should be useful for a variety of medicinal, agricultural, and materials chemists.

Citing Articles

Deoxytrifluoromethylation/aromatization of cyclohexan(en)ones to access highly substituted trifluoromethyl arenes.

Bhattarai P, Abd El-Gaber M, Koley S, Altman R Nat Commun. 2024; 15(1):7882.

PMID: 39251584 PMC: 11385238. DOI: 10.1038/s41467-024-52035-9.

Deoxytrifluoromethylation of Alcohols.

Intermaggio N, Millet A, Davis D, MacMillan D J Am Chem Soc. 2022; 144(27):11961-11968.

PMID: 35786873 PMC: 9676087. DOI: 10.1021/jacs.2c04807.

Recent trends in dehydroxylative trifluoro-methylation, -methoxylation, -methylthiolation, and -methylselenylation of alcohols.

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