Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2019 Jan 10

PMID 30621076

Citations 59

Authors

Yubo Liu

Weibing Ye

Qian Chen

Yong Zhang

Chia-Hua Kuo

Mallikarjuna Korivi

Affiliations

Soon will be listed here.

Abstract

We investigated the influence of resistance exercise (RE) with different intensities on HbA1c, insulin and blood glucose levels in patients with type 2 diabetes (T2D). Diabetes trials that compared RE group with a control were included in meta-analysis. Exercise intensities were categorized into low-to-moderate-intensity and high-intensity subgroups. Intensity effect on glycemic control was determined by meta-regression analysis, and risk-of-bias was assessed using Cochrane Collaboration tool. 24 trials met the inclusion criteria, comprised of 962 patients of exercise ( = 491) and control ( = 471). Meta-regression analysis showed decreased HbA1c ( = 0.006) and insulin ( = 0.015) after RE was correlated with intensity. Subgroup analysis revealed decreased HbA1c was greater with high intensity (-0.61; 95% CI -0.90, -0.33) than low-to-moderate intensity (-0.23; 95% CI -0.41, -0.05). Insulin levels were significantly decreased only with high intensity (-4.60; 95% CI -7.53, -1.67), not with low-to-moderate intensity (0.07; 95% CI -3.28, 3.42). Notably, values between the subgroups were statistically significant for both HbA1c ( = 0.03) and insulin ( = 0.04), indicative of profound benefits of high-intensity RE. Pooled outcomes of 15 trials showed only a decreased trend in blood glucose with RE ( = 0.09), and this tendency was not associated with intensity. Our meta-analysis provides additional evidence that high-intensity RE has greater beneficial effects than low-to-moderate-intensity in attenuation of HbA1c and insulin in T2D patients.

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