5-aminolevulinic Acid Induced Protoporphyrin IX (ALA-PpIX) Fluorescence Guidance in Meningioma Surgery

Overview

Journal J Neurooncol

Publisher Springer

Date 2019 Jan 4

PMID 30604395

Citations 22

Authors

Pablo A Valdes

Matthias Millesi

Georg Widhalm

David W Roberts

Affiliations

Soon will be listed here.

Abstract

Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors.

Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas.

Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas.

Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

Citing Articles

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Whole-body fluorescence cryotomography identifies a fast-acting, high-contrast, durable contrast agent for fluorescence-guided surgery.

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Black D, Byrne D, Walke A, Liu S, Ieva A, Kaneko S Commun Med (Lond). 2024; 4(1):131.

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Topographic Patterns of Intracranial Meningioma Recurrences-Systematic Review with Clinical Implication.

Corvino S, Altieri R, La Rocca G, Piazza A, Corazzelli G, Palmiero C Cancers (Basel). 2024; 16(12).

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da Silva Jr E, Ramina R, Filho J, Jung G, Bornancin G, Neto M J Neurooncol. 2024; 168(3):555-562.

PMID: 38709355 DOI: 10.1007/s11060-024-04698-z.

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