Electrostatically Interactive Injectable Hydrogels for Drug Delivery

Overview

Journal Tissue Eng Regen Med

Date 2019 Jan 4

PMID 30603575

Citations 14

Authors

Ji Young Seo

Bong Lee

Tae Woong Kang

Jung Hyun Noh

Min Ju Kim

Yun Bae Ji

Hyeon Jin Ju

Byoung Hyun Min

Moon Suk Kim

Affiliations

Soon will be listed here.

Abstract

Background: Several injectable hydrogels have been developed extensively for a broad range of biomedical applications. Injectable hydrogels forming through the change in external stimuli have the distinct properties of easy management and minimal invasiveness, and thus provide the advantage of bypassing surgical procedures for administration resulting in better patient compliance.

Methods: The injectable -forming hydrogels can be formed irreversibly or reversibly under physiological stimuli. Among several external stimuli that induce formation of hydrogels , in this review, we focused on the electrostatic interactions as the most simple and interesting stimulus.

Results: Currently, numerous polyelectrolytes have been reported as potential electrostatically interactive -forming hydrogels. In this review, a comprehensive overview of the rapidly developing electrostatically interactive -forming hydrogels, which are produced by various anionic and cationic polyelectrolytes such as chitosan, celluloses, and alginates, has been outlined and summarized. Further, their biomedical applications have also been discussed.

Conclusion: The review concludes with perspectives on the future of electrostatically interactive -forming hydrogels.

Citing Articles

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References

Cheng O, Souzdalnitski D, Vrooman B, Cheng J . Evidence-based knee injections for the management of arthritis. Pain Med. 2012; 13(6):740-53. PMC: 3376243. DOI: 10.1111/j.1526-4637.2012.01394.x. View

Raftery R, OBrien F, Cryan S . Chitosan for gene delivery and orthopedic tissue engineering applications. Molecules. 2013; 18(5):5611-47. PMC: 6270408. DOI: 10.3390/molecules18055611. View

Tahrir F, Ganji F, Ahooyi T . Injectable thermosensitive chitosan/glycerophosphate-based hydrogels for tissue engineering and drug delivery applications: a review. Recent Pat Drug Deliv Formul. 2014; 9(2):107-20. DOI: 10.2174/1872211308666141028145651. View

Zhang Z . Injectable biomaterials for stem cell delivery and tissue regeneration. Expert Opin Biol Ther. 2016; 17(1):49-62. DOI: 10.1080/14712598.2017.1256389. View

Cho K, Singh B, Maharjan S, Jang Y, Choi Y, Cho C . Local Delivery of CTGF siRNA with Poly(sorbitol-co-PEI) Reduces Scar Contraction in Cutaneous Wound Healing. Tissue Eng Regen Med. 2019; 14(3):211-220. PMC: 6171600. DOI: 10.1007/s13770-017-0059-9. View

Williams P, Campbell K, Silva E . Alginate hydrogels of varied molecular weight distribution enable sustained release of sphingosine-1-phosphate and promote angiogenesis. J Biomed Mater Res A. 2017; 106(1):138-146. PMC: 7255495. DOI: 10.1002/jbm.a.36217. View

Sobhani A, Rafienia M, Ahmadian M, Naimi-Jamal M . Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering. Tissue Eng Regen Med. 2019; 14(5):525-538. PMC: 6171629. DOI: 10.1007/s13770-017-0056-z. View

Kim K, Lee J, Ahn H, Lee J, Khang G, Lee B . The osteogenic differentiation of rat muscle-derived stem cells in vivo within in situ-forming chitosan scaffolds. Biomaterials. 2008; 29(33):4420-8. DOI: 10.1016/j.biomaterials.2008.08.005. View

Wei Z, Zhao J, Chen Y, Zhang P, Zhang Q . Self-healing polysaccharide-based hydrogels as injectable carriers for neural stem cells. Sci Rep. 2016; 6:37841. PMC: 5126669. DOI: 10.1038/srep37841. View

10.

Yang J, Zhang Y, Yue K, Khademhosseini A . Cell-laden hydrogels for osteochondral and cartilage tissue engineering. Acta Biomater. 2017; 57:1-25. PMC: 5545789. DOI: 10.1016/j.actbio.2017.01.036. View

11.

Wang C, Wang X, Dong K, Luo J, Zhang Q, Cheng Y . Injectable and responsively degradable hydrogel for personalized photothermal therapy. Biomaterials. 2016; 104:129-37. DOI: 10.1016/j.biomaterials.2016.07.013. View

12.

Shinya S, Fukamizo T . Interaction between chitosan and its related enzymes: A review. Int J Biol Macromol. 2017; 104(Pt B):1422-1435. DOI: 10.1016/j.ijbiomac.2017.02.040. View

13.

Zhao F, Wu D, Yao D, Guo R, Wang W, Dong A . An injectable particle-hydrogel hybrid system for glucose-regulatory insulin delivery. Acta Biomater. 2017; 64:334-345. DOI: 10.1016/j.actbio.2017.09.044. View

14.

Shen Y, Cho H, Papa A, Burke J, Chan X, Duh E . Engineered human vascularized constructs accelerate diabetic wound healing. Biomaterials. 2016; 102:107-19. DOI: 10.1016/j.biomaterials.2016.06.009. View

15.

Borges J, Mano J . Molecular interactions driving the layer-by-layer assembly of multilayers. Chem Rev. 2014; 114(18):8883-942. DOI: 10.1021/cr400531v. View

16.

Jho Y, Yoo H, Lin Y, Han S, Hwang D . Molecular and structural basis of low interfacial energy of complex coacervates in water. Adv Colloid Interface Sci. 2016; 239:61-73. DOI: 10.1016/j.cis.2016.07.003. View

17.

Mun C, Hwang J, Lee S . Microfluidic spinning of the fibrous alginate scaffolds for modulation of the degradation profile. Tissue Eng Regen Med. 2019; 13(2):140-148. PMC: 6170856. DOI: 10.1007/s13770-016-9048-7. View

18.

Jin G, Kim H . Effects of Type I Collagen Concentration in Hydrogel on the Growth and Phenotypic Expression of Rat Chondrocytes. Tissue Eng Regen Med. 2019; 14(4):383-391. PMC: 6171609. DOI: 10.1007/s13770-017-0060-3. View

19.

Kim D, Kwon D, Kwon J, Park J, Park S, Oh H . Synergistic anti-tumor activity through combinational intratumoral injection of an in-situ injectable drug depot. Biomaterials. 2016; 85:232-45. DOI: 10.1016/j.biomaterials.2016.02.001. View

20.

Udoetok I, Wilson L, Headley J . Quaternized Cellulose Hydrogels as Sorbent Materials and Pickering Emulsion Stabilizing Agents. Materials (Basel). 2017; 9(8). PMC: 5509095. DOI: 10.3390/ma9080645. View