Stem Cell Dynamics, Migration and Plasticity During Wound Healing

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2019 Jan 4

PMID 30602767

Citations 141

Authors

Sophie Dekoninck

Cedric Blanpain

Affiliations

Soon will be listed here.

Abstract

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem cells recruited from various skin regions together with other cell types, including fibroblasts and immune cells, is required to ensure efficient and harmonious wound healing. A complex crosstalk ensures the activation, migration and plasticity of these cells during tissue repair.

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References

Szpaderska A, Zuckerman J, DiPietro L . Differential injury responses in oral mucosal and cutaneous wounds. J Dent Res. 2003; 82(8):621-6. DOI: 10.1177/154405910308200810. View

Hughes M, Jiang T, Plikus M, Guerrero-Juarez C, Lin C, Schafer C . Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis. J Invest Dermatol. 2018; 138(9):2041-2050. PMC: 6109435. DOI: 10.1016/j.jid.2018.02.043. View

Batlle E, Henderson J, Beghtel H, van den Born M, Sancho E, Huls G . Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell. 2002; 111(2):251-63. DOI: 10.1016/s0092-8674(02)01015-2. View

Doupe D, Alcolea M, Roshan A, Zhang G, Klein A, Simons B . A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science. 2012; 337(6098):1091-3. PMC: 3527005. DOI: 10.1126/science.1218835. View

Argyris T . Kinetics of epidermal production during epidermal regeneration following abrasion in mice. Am J Pathol. 1976; 83(2):329-40. PMC: 2032312. View

Zhang Y, Tomann P, Andl T, Gallant N, Huelsken J, Jerchow B . Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009; 17(1):49-61. PMC: 2859042. DOI: 10.1016/j.devcel.2009.05.011. View

Gay D, Kwon O, Zhang Z, Spata M, Plikus M, Holler P . Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med. 2013; 19(7):916-23. PMC: 4054871. DOI: 10.1038/nm.3181. View

Doupe D, Klein A, Simons B, Jones P . The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell. 2010; 18(2):317-23. DOI: 10.1016/j.devcel.2009.12.016. View

Aragona M, Dekoninck S, Rulands S, Lenglez S, Mascre G, Simons B . Defining stem cell dynamics and migration during wound healing in mouse skin epidermis. Nat Commun. 2017; 8:14684. PMC: 5339881. DOI: 10.1038/ncomms14684. View

10.

Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A . Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports. 2015; 5(5):843-855. PMC: 4649262. DOI: 10.1016/j.stemcr.2015.09.013. View

11.

Mannik J, Alzayady K, Ghazizadeh S . Regeneration of multilineage skin epithelia by differentiated keratinocytes. J Invest Dermatol. 2009; 130(2):388-97. PMC: 2879264. DOI: 10.1038/jid.2009.244. View

12.

Jones P, Watt F . Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell. 1993; 73(4):713-24. DOI: 10.1016/0092-8674(93)90251-k. View

13.

Rognoni E, Gomez C, Pisco A, Rawlins E, Simons B, Watt F . Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing. Development. 2016; 143(14):2522-35. PMC: 4958333. DOI: 10.1242/dev.131797. View

14.

Hsu Y, Li L, Fuchs E . Emerging interactions between skin stem cells and their niches. Nat Med. 2014; 20(8):847-56. PMC: 4358898. DOI: 10.1038/nm.3643. View

15.

Nelson A, Loy D, Lawson J, Katseff A, FitzGerald G, Garza L . Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. J Invest Dermatol. 2012; 133(4):881-9. PMC: 3593761. DOI: 10.1038/jid.2012.398. View

16.

Nelson A, Reddy S, Ratliff T, Hossain M, Katseff A, Zhu A . dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell. 2015; 17(2):139-51. PMC: 4529957. DOI: 10.1016/j.stem.2015.07.008. View

17.

Wankell M, Munz B, Hubner G, Hans W, Wolf E, Goppelt A . Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis. EMBO J. 2001; 20(19):5361-72. PMC: 125651. DOI: 10.1093/emboj/20.19.5361. View

18.

Haensel D, Dai X . Epithelial-to-mesenchymal transition in cutaneous wound healing: Where we are and where we are heading. Dev Dyn. 2017; 247(3):473-480. PMC: 5809211. DOI: 10.1002/dvdy.24561. View

19.

Levy V, Lindon C, Zheng Y, Harfe B, Morgan B . Epidermal stem cells arise from the hair follicle after wounding. FASEB J. 2007; 21(7):1358-66. DOI: 10.1096/fj.06-6926com. View

20.

Rodgers J, King K, Brett J, Cromie M, Charville G, Maguire K . mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014; 510(7505):393-6. PMC: 4065227. DOI: 10.1038/nature13255. View